"DOT1L" Related Products


Recombinant Human DOT1L protein, GST-tagged

Cat.No.: DOT1L-256H
Product Overview: Recombinant Human DOT1L(1-472 aa)(Catalytic Domain) fused with GST tag at N-terminal was expressed in E. coli.
Description: DOT1 is a histone methyltransferase, catalyzing the methylation of histone H3 at lysine 79 on nucleosomal substrates.
Source: E. coli
Species: Human
Tag : GST
Form: 100 mM Tris pH 8.0, 5 mM glutathione and 25% glycerol.
Molecular Mass: 85 kDa
Applications: Recombinant DOT1L Catalytic Domain, human is useful for histone H3 methylation experiments, enzyme kinetics and inhibitor screening. Use of 3-5 µg DOT1L per reaction with HeLa or recombinant nucleosomes as a substrate is recommended.
Storage: Stable for six months at -80 centigrade from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.
Concentration: 1 µg/µl
Gene Name: DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) [ Homo sapiens ]
Official Symbol: DOT1L
Synonyms: DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisiae); histone-lysine N-methyltransferase, H3 lysine-79 specific; DOT1; histone methyltransferase DOT1L; KIAA1814; KMT4; H3-K79-HMTase; DOT1-like protein; lysine N-methyltransferase 4; histone H3-K79 methyltransferase; DKFZp586P1823;
Gene ID: 84444
mRNA Refseq: NM_032482
Protein Refseq: NP_115871
MIM: 607375
UniProt ID: Q8TEK3
Chromosome Location: 19p13.3
Pathway: Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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