Recombinant Human EGFR protein

• Cat.No.: EGFR-201H
• Product Overview: Recombinant Human EGFR, transcript variant 3, was expressed in CHO.

Specification

• Description: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.
• Source: CHO
• Species: Human
• Form: Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer, 100mM NaCl, pH 7.2
• Molecular Mass: 97.5 kDa
• AA Sequence: LEEKKVCQGTSNKLTQLGTFEDHFL SLQRMFNNCEVVLGNLEITYVQRNY DLSFLKTIQEVAGYVLIALNTVERI PLENLQIIRGNMYYENSYALAVLSN YDANKTGLKELPMRNLQEILHGAVR FSNNPALCNVESIQWRDIVSSDFLS NMSMDFQNHLGSCQKCDPSCPNGSC WGAGEENCQKLTKIICAQQCSGRCR GKSPSDCCHNQCAAGCTGPRESDCL VCRKFRDEATCKDTCPPLMLYNPTT YQMDVNPEGKYSFGATCVKKCPRNY VVTDHGSCVRACGADSYEMEEDGVR KCKKCEGPCRKVCNGIGIGEFKDSL SINATNIKHFKNCTSISGDLHILPV AFRGDSFTHTPPLDPQELDILKTVK EITGFLLIQAWPENRTDLHAFENLE IIRGRTKQHGQFSLAVVSLNITSLG LRSLKEISDGDVIISGNKNLCYANT INWKKLFGTSGQKTKIISNRGENSC KATGQVCHALCSPEGCWGPEPRDCV SCRNVSRGRECVDKCNLLEGEPREF VENSECIQCHPECLPQAMNITCTGR GPDNCIQCAHYIDGPHCVKTCPAGV MGENNTLVWKYADAGHVCHLCHPNC TYGCTGPGLEGCPTNGPKIPS
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: Resuspend the protein in the desired concentration in proper buffer

Gene Information

• Gene Name: EGFR epidermal growth factor receptor [ Homo sapiens ]
• Official Symbol: EGFR
• Synonyms: EGFR; epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) , ERBB; ERBB1; erythroblastic leukemia viral (v erb b) oncogene homolog (avian); proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; ERBB; HER1; mENA; PIG61
• Gene ID: 1956
• mRNA Refseq: NM_201283
• Protein Refseq: NP_958440
• MIM: 131550
• UniProt ID: P00533