| Description : |
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016] |
| Source : |
HEK293 cells |
| Species : |
Human |
| Tag : |
Fc |
| Molecular Mass : |
rhEGFR-Fc is a homodimeric protein and is fused with the Fc region of human IgG1 at the C-terminus. The reduced monomer consists of 860 amino acids and has a calculated molecular mass of 95 kDa. The predicted N-terminal is Leu 25. In DTT-reduced SDS-PAGE, protein migrates as 130-140 kDa. |
| Endotoxin : |
Less than 0.01 ng endotoxin/1 µg rhEGFR-Fc. |
| Purity : |
>95% purity as determined by SDS-PAGE of reduced rhEGFR-Fc. |
| Notes : |
Research Use Only. Not for use in diagnostic or therapeutic procedures. |
| Storage : |
Store at -20 centigrade in lyophilized state after receipt. For long term storage, upon reconstitution rhEGFR-Fc should be aliquot and store at -20 centigrade or -8 centigrade centigrade. Avoid repeated freeze-thaw cycles. |
| Storage Buffer : |
Bulk protein in a 0.22 µm filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization. |
