Active Recombinant Human EGFR Protein, His-tagged
Cat.No. : | EGFR-202H |
Product Overview : | Recombinant Human EGFR(25-647 aa, signal peptide removed) fused with His at C-terminal tag was expressed in CHO. |
- Specification
- Gene Information
- Related Products
Description : | As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently. |
Source : | CHO |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Leu 25 |
Form : | Lyophilized from sterile PBS, pH 7.4 |
Bio-activity : | Measured by its binding ability in a functional ELISA. |
Molecular Mass : | The recombinant mature human EGFR protein consists of 629 amino acids and has a calculated molecular mass of 69.6 KD. |
Protein length : | 25-647 aa |
Endotoxin : | <1.0 EU/ug, LAL method |
Purity : | >95%(SDS-PAGE) |
Stability : | Stable for up to twelve months from date of receipt at -70 centigrade |
Storage : | Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | EGFR epidermal growth factor receptor [ Homo sapiens ] |
Official Symbol : | EGFR |
Synonyms : | EGFR; epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) , ERBB; ERBB1; erythroblastic leukemia viral (v erb b) oncogene homolog (avian); proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; ERBB; HER1; mENA; PIG61; |
Gene ID : | 1956 |
mRNA Refseq : | NM_005228 |
Protein Refseq : | NP_005219 |
MIM : | 131550 |
UniProt ID : | P00533 |
Products Types
◆ Recombinant Protein | ||
EGFR-65H | Recombinant Human EGFR Protein (ECD), His-tagged(C-ter) | +Inquiry |
EGFR-076H | Recombinant Human EGFR Protein, DYKDDDDK-tagged | +Inquiry |
EGFR-168C | Active Recombinant Canine EGFR protein(Met1-Ser618), His-tagged | +Inquiry |
EGFR-901H | Recombinant Human EGFR Protein, His-tagged | +Inquiry |
EGFR-215R | Recombinant Rhesus macaque EGFR Protein, His-tagged | +Inquiry |
◆ Lysates | ||
EGFR-2733HCL | Recombinant Human EGFR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket