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Recombinant Human ERN1 Protein, His-tagged

Cat.No. : ERN1-1490H
Product Overview : Recombinant Human ERN1 Protein (Phe571~Phe832) was expressed in E. coli with N-terminal His Tag.
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Description : This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
Source : E. coli
Species : Human
Tag : His
Form : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Molecular Mass : 33.3kDa
Purity : > 97%
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Gene Name : ERN1 endoplasmic reticulum to nucleus signaling 1 [ Homo sapiens (human) ]
Official Symbol : ERN1
Synonyms : IRE1; IRE1P; IRE1a; hIRE1p
Gene ID : 2081
mRNA Refseq : NM_001433.4
Protein Refseq : NP_001424.3
MIM : 604033
UniProt ID : O75460

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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