Recombinant Human EZH2 Complex protein, His-tagged
Cat.No. : | EZH2-170H |
Product Overview : | Mutant version of EZH2 5-member complex, but with a Tyr-to-His mutation on a.a. 646 of the QA EZH2 protein. Complex of human EZH2 (GenBank Accession No. NM_004456), a.a. 2-end; Y646H*, with N-terminal His tag, MW= 86 kDa, human EED (NM_003797), a.a. 2-end with N-terminal Flag tag, MW= 51 kDa, human SUZ12 (NM_015355), a.a. 2-end with N-terminal His tag, MW = 87 kDa, Human AEBP2 (NM_153207), a.a. 2-end with N-terminal His tag, MW= 53 kDa, and human RbAp48 (NM_005610), a.a. 2-end with N-terminal His tag, MW = 48 kDa, co-expressed in baculovirus expression system. |
- Specification
- Gene Information
- Related Products
Source : | Insect cells |
Species : | Human |
Tag : | His |
Form : | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol. |
Molecular Mass : | 325 kDa (complex) |
Protein length : | 2–end (all components) |
Purity : | ≥ 91% |
Applications : | Useful for Western blot analysis and to investigate protein-protein interactions in the EZH2 complex. |
Storage : | >6 months at -80 centigrade. Avoid freeze/thaw cycles |
Concentration : | 0.35 mg/ml |
Gene Name : | EZH2 enhancer of zeste homolog 2 (Drosophila) [ Homo sapiens ] |
Official Symbol : | EZH2 |
Synonyms : | EZH2; enhancer of zeste homolog 2 (Drosophila); enhancer of zeste (Drosophila) homolog 2; histone-lysine N-methyltransferase EZH2; ENX 1; EZH1; KMT6; KMT6A; lysine N-methyltransferase 6; ENX1; WVS2; ENX-1; MGC9169; |
Gene ID : | 2146 |
mRNA Refseq : | NM_004456 |
Protein Refseq : | NP_004447 |
MIM : | 601573 |
UniProt ID : | Q15910 |
Chromosome Location : | 7q35-q36 |
Function : | DNA binding; histone methyltransferase activity; histone-lysine N-methyltransferase activity; methyltransferase activity; protein binding; transferase activity; |
Products Types
◆ Recombinant Protein | ||
EZH2-1353R | Recombinant Rhesus Macaque EZH2 Protein, His (Fc)-Avi-tagged | +Inquiry |
EZH2-46H | Recombinant Human EZH2 Protein, His-tagged | +Inquiry |
EZH2-879H | Recombinant Human EZH2 Protein, His (Fc)-Avi-tagged | +Inquiry |
EZH2-285H | Recombinant Human EZH2 Protein, GST-tagged | +Inquiry |
Ezh2-991M | Recombinant Mouse Ezh2 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
EZH2-6487HCL | Recombinant Human EZH2 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1724 | EZH2 (Y641F) Chemiluminescent Assay Kit | +Inquiry |
Kit-1726 | EZH2 Chemiluminescent Assay Kit | +Inquiry |
Kit-1723 | EZH2 (A677G) Chemiluminescent Assay Kit | +Inquiry |
Kit-1727 | EZH2 Homogeneous Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionEZH2 overexpression is associated with promoting tumor cell proliferation, invasion, and metastasis, leading to cancer progression.
EZH2 has been implicated in various non-oncological conditions, including cardiovascular diseases and neurodegenerative disorders.
Potential side effects may include hematological toxicity, gastrointestinal issues, and liver enzyme elevation.
Small molecule inhibitors of EZH2 have been developed and are being investigated as potential cancer therapies.
High EZH2 expression has been associated with poor prognosis in several cancer types.
Customer Reviews (3)
Write a reviewThe versatility of the EZH2 protein is truly remarkable, as it can be employed across a wide range of applications in my research.
In addition to its outstanding quality, the manufacturer of the EZH2 protein offers excellent technical support that can effectively address any challenges I may encounter.
Their dedicated team of experts is readily available to provide guidance and assistance, ensuring a seamless integration of the EZH2 protein into my experimental setup.
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