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Recombinant Human EZH2 Protein, His-tagged

Cat.No. : EZH2-42H
Product Overview : Recombinant Human EZH2(C-term-306aa) fused with His tag was expressed in E. coli.
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  • Gene Information
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Description : This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
Source : E. coli
Species : Human
Tag : His
Form : The purified protein was resolved in 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7. ) added with 300mM Imidazole and 15%glycerol.
Protein length : C-term-306aa
AA Sequence : RVLIGTYYDNFCAIARLIGTKTCRQ VYEFRVKESSIIAPAPAEDVDTPPR KKKRKHRLWAAHCRKIQLKKDGSSN HVYNYQPCDHPRQPCDSSCPCVIAQ NFCEKFCQCSSECQNRFPGCRCKAQ CNTKQCPCYLAVRECDPDLCLTCGA ADHWDSKNVSCKNCSIQRGSKKHLL LAPSDVAGWGIFIKDPVQKNEFISE YCGEIISQDEADRRGKVYDKYMCSF LFNLNNDFVVDATRKGNKIRFANHS VNPNCYAKVMMVNGDHRIGIFAKRA IQTGEELFFDYRYSQADALKYVGIE REMEIP
Storage : Aliquot and store at -20 centigrade to -80 centigrade for up to 6 months. Avoid freeze thaw cycles.
Shipping : The product is shipped with ice packs. Upon receipt, store it immediately at -20 centigrade to -80 centigrade.
Gene Name : EZH2 enhancer of zeste homolog 2 (Drosophila) [ Homo sapiens ]
Official Symbol : EZH2
Synonyms : EZH2; enhancer of zeste homolog 2 (Drosophila); enhancer of zeste (Drosophila) homolog 2; histone-lysine N-methyltransferase EZH2; ENX 1; EZH1; KMT6; KMT6A; lysine N-methyltransferase 6; ENX1; WVS2; ENX-1; MGC9169;
Gene ID : 2146
mRNA Refseq : NM_004456
Protein Refseq : NP_004447
MIM : 601573
UniProt ID : Q15910

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is EZH2 overexpression associated with cancer progression? 11/20/2019

EZH2 overexpression is associated with promoting tumor cell proliferation, invasion, and metastasis, leading to cancer progression.

Are there any non-oncological clinical applications of EZH2? 07/29/2019

EZH2 has been implicated in various non-oncological conditions, including cardiovascular diseases and neurodegenerative disorders.

What are the potential side effects of EZH2 inhibitors in clinical use? 03/15/2017

Potential side effects may include hematological toxicity, gastrointestinal issues, and liver enzyme elevation.

How can EZH2 be targeted for cancer therapy? 08/17/2016

Small molecule inhibitors of EZH2 have been developed and are being investigated as potential cancer therapies.

Are there any prognostic implications of EZH2 expression in cancer patients? 08/15/2016

High EZH2 expression has been associated with poor prognosis in several cancer types.

Customer Reviews (3)

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Reviews
10/17/2022

    The versatility of the EZH2 protein is truly remarkable, as it can be employed across a wide range of applications in my research.

    03/14/2018

      In addition to its outstanding quality, the manufacturer of the EZH2 protein offers excellent technical support that can effectively address any challenges I may encounter.

      02/27/2018

        Their dedicated team of experts is readily available to provide guidance and assistance, ensuring a seamless integration of the EZH2 protein into my experimental setup.

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