Recombinant Human F3 Protein

• Cat.No.: F3-3619H
• Product Overview: Human F3 full-length ORF (AAH11029.1) recombinant protein without tag.

Specification

• Description: This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
• Source: Wheat Germ
• Species: Human
• Form: Liquid
• Molecular Mass: 33.1 kDa
• AA Sequence: METPAWPRVPRPETAVARTLLLGWV FAQVAGASGTTNTVAAYNLTWKSTN FKTILEWEPKPVNQVYTVQISTKSG DWKSKCFYTTDTECDLTDEIVKDVK QTYLARVFSYPAGNVESTGSAGEPL YENSPEFTPYLETNLGQPTIQSFEQ VGTKVNVTVEDERTLVRRNNTFLSL RDVFGKDLIYTLYYWKSSSSGKKTA KTNTNEFLIDVDKGENYCFSVQAVI PSRTVNRKSTDSPVECMGQEKGEFR EIFYIIGAVVFVVIILVIILAISLH KCRKAGVGQSWKENSPLNVS
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Usage: Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH 8.0 containing 2% glycerol.

Gene Information

• Gene Name: F3 coagulation factor III (thromboplastin, tissue factor) [ Homo sapiens ]
• Official Symbol: F3
• Synonyms: F3; coagulation factor III (thromboplastin, tissue factor); tissue factor; CD142; TF; TFA; FLJ17960
• Gene ID: 2152
• mRNA Refseq: NM_001178096
• Protein Refseq: NP_001171567
• MIM: 134390
• UniProt ID: P13726