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Recombinant Human F7 Protein, GST-tagged

Cat.No. : F7-3622H
Product Overview : Human F7 full-length ORF ( NP_062562.1, 1 a.a. - 444 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 75.7 kDa
AA Sequence : MVSQALRLLCLLLGLQGCLAAVFVT QEEAHGVLHRRRRANAFLEELRPGS LERECKEEQCSFEEAREIFKDAERT KLFWISYSDGDQCASSPCQNGGSCK DQLQSYICFCLPAFEGRNCETHKDD QLICVNENGGCEQYCSDHTGTKRSC RCHEGYSLLADGVSCTPTVEYPCGK IPILEKRNASKPQGRIVGGKVCPKG ECPWQVLLLVNGAQLCGGTLINTIW VVSAAHCFDKIKNWRNLIAVLGEHD LSEHDGDEQSRRVAQVIIPSTYVPG TTNHDIALLRLHQPVVLTDHVVPLC LPERTFSERTLAFVRFSLVSGWGQL LDRGATALELMVLNVPRLMTQDCLQ QSRKVGDSPNITEYMFCAGYSDGSK DSCKGDSGGPHATHYRGTWYLTGIV SWGQGCATVGHFGVYTRVSQYIEWL QKLMRSEPRPGVLLRAPFP
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : F7 coagulation factor VII (serum prothrombin conversion accelerator) [ Homo sapiens ]
Official Symbol : F7
Synonyms : F7; coagulation factor VII (serum prothrombin conversion accelerator); coagulation factor VII; eptacog alfa; factor VII; FVII coagulation protein; SPCA; proconvertin; serum prothrombin conversion accelerator;
Gene ID : 2155
mRNA Refseq : NM_000131
Protein Refseq : NP_000122
MIM : 613878
UniProt ID : P08709

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does F7 contribute to hemostasis, and what is its role in preventing excessive bleeding? 04/02/2021

Factor VII's role in the coagulation cascade ensures rapid initiation of clot formation, preventing excessive bleeding and contributing to hemostasis.

Discuss the role of F7 in the extrinsic pathway of blood coagulation. 07/20/2020

Factor VII is a key player in the extrinsic pathway, where it forms a complex with tissue factor to activate factor X, initiating the cascade leading to thrombin generation.

What are the mechanisms of F7 activation, and how is it regulated at the molecular level? 01/15/2019

Factor VII is activated through a proteolytic cleavage, converting it into its active form (VIIa). This activation is regulated by tissue factor and other coagulation factors.

Explain the biochemical basis of F7 deficiency and its implications for bleeding disorders. 11/05/2018

F7 deficiency results in impaired blood clotting, leading to a bleeding disorder known as coagulation factor VII deficiency. This condition can manifest in varying degrees of severity.

Explain the role of F7 in the coagulation cascade and blood clot formation. 09/28/2018

Factor VII is activated to its enzymatically active form (factor VIIa) and initiates the coagulation cascade by activating factor X, ultimately leading to the formation of a stable blood clot.

Customer Reviews (3)

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Reviews
05/18/2022

    Quick turnaround—this product arrived swiftly, facilitating our research.

    10/03/2019

      Exceptional quality and precision—our lab relies on this protein consistently.

      05/29/2018

        Invaluable assistance from customer service—professional and responsive.

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