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Recombinant Human F8 Protein, His-tagged

Cat.No. : F8-048H
Product Overview : Purified recombinant protein of Human coagulation factor VIII, procoagulant component (F8), transcript variant 2, full length, with N-terminal HIS tag, expressed in E. coli.
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Description : This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 24.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 µg/mL as determined by microplate BCA method
Storage Buffer : 50mM Tris, 8M Urea, pH 8.0.
Gene Name : F8 coagulation factor VIII, procoagulant component [ Homo sapiens ]
Official Symbol : F8
Synonyms : F8; coagulation factor VIII, procoagulant component; F8C; coagulation factor VIII; DXS1253E; Factor VIIIF8B; FVIII; HEMA; hemophilia A; factor VIII F8B; antihemophilic factor; coagulation factor VIIIc; AHF; F8B;
Gene ID : 2157
mRNA Refseq : NM_000132
Protein Refseq : NP_000123
MIM : 300841
UniProt ID : P00451

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How has technology advanced the production of F8 protein for therapeutic purposes? 04/26/2023

Recombinant DNA technology allows for the production of F8 protein in laboratory settings, reducing the risk of contamination and increasing availability.

Can F8 protein therapy be administered at home by patients? 01/12/2020

Many patients can self-administer F8 protein therapy at home after proper training, providing convenience and improving overall quality of life.

Are there alternative treatment approaches for hemophilia A involving F8 protein? 12/13/2019

Gene therapy is being explored as a potential alternative, aiming to introduce functional F8 genes into patients' cells to produce the missing protein.

How does monitoring F8 protein levels contribute to hemophilia A management? 01/14/2019

Regular monitoring helps determine the appropriate dosage for replacement therapy, ensuring that F8 levels remain within the therapeutic range.

Are there any complications associated with F8 protein replacement therapy? 01/19/2018

In some cases, individuals may develop inhibitors—antibodies that neutralize the therapeutic F8 protein—leading to challenges in treatment.

Customer Reviews (3)

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Reviews
01/04/2023

    The F8 protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.

    04/26/2019

      Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.

      06/17/2017

        With its consistent and outstanding results, the F8 protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.

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