Recombinant Human F8 Protein, His-tagged
Cat.No. : | F8-048H |
Product Overview : | Purified recombinant protein of Human coagulation factor VIII, procoagulant component (F8), transcript variant 2, full length, with N-terminal HIS tag, expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | 24.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 µg/mL as determined by microplate BCA method |
Storage Buffer : | 50mM Tris, 8M Urea, pH 8.0. |
Gene Name : | F8 coagulation factor VIII, procoagulant component [ Homo sapiens ] |
Official Symbol : | F8 |
Synonyms : | F8; coagulation factor VIII, procoagulant component; F8C; coagulation factor VIII; DXS1253E; Factor VIIIF8B; FVIII; HEMA; hemophilia A; factor VIII F8B; antihemophilic factor; coagulation factor VIIIc; AHF; F8B; |
Gene ID : | 2157 |
mRNA Refseq : | NM_000132 |
Protein Refseq : | NP_000123 |
MIM : | 300841 |
UniProt ID : | P00451 |
Products Types
◆ Recombinant Protein | ||
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F8-1452C | Recombinant Chicken F8 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
F8-6482HCL | Recombinant Human F8 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionRecombinant DNA technology allows for the production of F8 protein in laboratory settings, reducing the risk of contamination and increasing availability.
Many patients can self-administer F8 protein therapy at home after proper training, providing convenience and improving overall quality of life.
Gene therapy is being explored as a potential alternative, aiming to introduce functional F8 genes into patients' cells to produce the missing protein.
Regular monitoring helps determine the appropriate dosage for replacement therapy, ensuring that F8 levels remain within the therapeutic range.
In some cases, individuals may develop inhibitors—antibodies that neutralize the therapeutic F8 protein—leading to challenges in treatment.
Customer Reviews (3)
Write a reviewThe F8 protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.
Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.
With its consistent and outstanding results, the F8 protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.
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