"FASLG" Related Products

Recombinant Human FASLG protein, His-tagged

Cat.No.: FASLG-15H
Product Overview: Human Fas Ligand, His Tag (FAL-H5241) is expressed from human 293 cells (HEK293). It contains AA Pro 134 - Leu 281 (Accession # AAH17502.1).
Description: Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.
Source: HEK293
Species: Human
Tag : His
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Molecular Mass: The protein has a calculated MW of 17.7 kDa. The protein migrates as 25-32 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
Endotoxin: Less than 1.0 EU per μg by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. 4-8 centigrade for 12 months in lyophilized state. -70 centigrade for 3 months under sterile conditions after reconstitution.
Gene Name: FASLG Fas ligand (TNF superfamily, member 6) [ Homo sapiens ]
Official Symbol: FASLG
Synonyms: FASLG,ALPS1B,APT1LG1,CD178,CD95L,FASL,TNFSF6
Gene ID: 356
mRNA Refseq: NM_000639
Protein Refseq: NP_000630
MIM: 134638
UniProt ID: P48023

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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