|Product Overview:||Recombinant Human FCAMR(Leu17-Arg450) fused with His tag at C-terminal was expressed in CHO.|
|Description:||Fc alpha/mu Receptor (FCAMR), designated CD351, is an approximately 60 kDa transmembrane protein that serves as a receptor for IgA and IgM immunoglobulins. Mature human FCAMR consists of a 434 amino acid (aa) extracellular domain with one Ig-like domain, a 21 aa transmembrane segment, and a 61 aa cytoplasmic domain. Within the ECD, human FCAMR shares 51% aa sequence identity with mouse and rat FCAMR. Alternative splicing generates additional isoforms that are truncated following the Ig-like domain, are truncated before the transmembrane segment, or carry a 9 aa deletion and a substitution of the transmembrane segment. FCAMR is expressed on B cells, macrophages, and kidney mesangial cells. It binds to both IgA and IgM in immune complexes but not to monomeric immunoglobulin. FCAMR participates in pathogen clearance as well as foam cell formation by mediating the internalization of IgM-opsonized microbes and oxidized LDL-containing particles.|
|Predicted N Terminal:||Leu17|
|Form:||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Bio-activity:||Measured by its binding ability in a functional ELISA. When Human IgM is immobilized at 2.5 μg/mL, 100 μL/well, the concentration of Recombinant Human Fc alpha /μ R that produces 50% of the optimal binding response is approximately 0.12-0.72 μg/mL.|
|Molecular Mass:||Predicted Molecular Mass: 47 kDa
SDS-PAGE: 84-108 kDa, reducing conditions
|Endotoxin:||<0.1 EU per 1 μg of the protein by the LAL method.|
|Purity:||>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.|
|Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
|Reconstitution:||Reconstitute at 500 μg/mL in PBS.|
|Gene Name:||FCAMR Fc fragment of IgA and IgM receptor [ Homo sapiens ]|
|Synonyms:||CD351; FCA/MR; FKSG87; Fc alpha/mu receptor; Fc receptor, IgA, IgM, high affinity; immunity related factor; receptor for Fc fragment of IgA and IgM|
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