Recombinant Human FGFR2 Protein, DDK-tagged
Cat.No. : | FGFR2-2055H |
Product Overview : | Recombinant human FGFR2 protein, fused to DDK-tagged at C-terminus, was expressed in Insect cells |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]. |
Source : | Insect cells |
Species : | Human |
Tag : | DDK |
Form : | 50 mM Tris-HCl, pH 8.0, 100 mM glycine, 10% glycerol. Store at -80 Centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions. |
Molecular Mass : | 39.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens ] |
Official Symbol : | FGFR2 |
Synonyms : | BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25 |
Gene ID : | 2263 |
mRNA Refseq : | NM_000141 |
Protein Refseq : | NP_000132 |
MIM : | 176943 |
UniProt ID : | P21802 |
Products Types
◆ Recombinant Protein | ||
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FGFR2-5418H | Recombinant Human Fibroblast Growth Factor Receptor 2, His-tagged | +Inquiry |
FGFR2-058H | Recombinant Human FGFR2 Protein | +Inquiry |
FGFR2-705H | Active Recombinant Human FGFR2 protein(Met1-Glu377), His&hFc-tagged | +Inquiry |
Fgfr2-135M | Recombinant Mouse Fgfr2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
FGFR2-001MCL | Recombinant Mouse FGFR2 cell lysate | +Inquiry |
FGFR2-2578HCL | Recombinant Human FGFR2 cell lysate | +Inquiry |
FGFR2-428HCL | Recombinant Human FGFR2 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0341 | FGFR2 Kinase (Human) Assay/Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionMutations in FGFR2 are associated with various developmental disorders, impacting the development of the skull, limbs, and other structures.
Yes, targeting FGFR2 mutations allows for more personalized and precise therapeutic approaches in cancer treatment.
Yes, numerous clinical trials are underway to evaluate the efficacy of FGFR2 inhibitors in treating various cancers and developmental disorders.
FGFR2 is involved in the regulation of cell migration and tissue repair, contributing to the process of wound healing.
Common side effects of FGFR2 inhibitors include fatigue, nausea, and hypertension, which are being studied for better management.
Customer Reviews (3)
Write a reviewThe FGFR2 protein is an outstanding product that possesses exceptional quality, making it an ideal choice for my experimental needs.
What sets FGFR2 apart is the manufacturer's unparalleled technical support.
The versatility of the FGFR2 protein makes it a valuable asset in my research.
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