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Recombinant Human FGFR2 Protein, DDK-tagged

Cat.No. : FGFR2-2055H
Product Overview : Recombinant human FGFR2 protein, fused to DDK-tagged at C-terminus, was expressed in Insect cells
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  • Gene Information
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Description : The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].
Source : Insect cells
Species : Human
Tag : DDK
Form : 50 mM Tris-HCl, pH 8.0, 100 mM glycine, 10% glycerol. Store at -80 Centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Molecular Mass : 39.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens ]
Official Symbol : FGFR2
Synonyms : BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25
Gene ID : 2263
mRNA Refseq : NM_000141
Protein Refseq : NP_000132
MIM : 176943
UniProt ID : P21802

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is FGFR2 linked to developmental disorders? 01/01/2022

Mutations in FGFR2 are associated with various developmental disorders, impacting the development of the skull, limbs, and other structures.

Can FGFR2 be targeted for personalized cancer therapy? 04/19/2021

Yes, targeting FGFR2 mutations allows for more personalized and precise therapeutic approaches in cancer treatment.

Are there clinical trials involving FGFR2 inhibitors? 01/24/2020

Yes, numerous clinical trials are underway to evaluate the efficacy of FGFR2 inhibitors in treating various cancers and developmental disorders.

How does FGFR2 impact wound healing? 02/28/2019

FGFR2 is involved in the regulation of cell migration and tissue repair, contributing to the process of wound healing.

Are there any side effects associated with FGFR2 inhibitors? 08/28/2018

Common side effects of FGFR2 inhibitors include fatigue, nausea, and hypertension, which are being studied for better management.

Customer Reviews (3)

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Reviews
08/24/2017

    The FGFR2 protein is an outstanding product that possesses exceptional quality, making it an ideal choice for my experimental needs.

    03/05/2017

      What sets FGFR2 apart is the manufacturer's unparalleled technical support.

      09/13/2016

        The versatility of the FGFR2 protein makes it a valuable asset in my research.

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