Recombinant Human FOXO1 protein, MYC/DDK-tagged

• Cat.No.: FOXO1-146H
• Product Overview: Recombinant Human FOXO1 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 69.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: FOXO1 forkhead box O1 [ Homo sapiens ]
• Official Symbol: FOXO1
• Synonyms: FOXO1; forkhead box O1; FKHR, forkhead homolog in rhabdomyosarcoma , FOXO1A; forkhead box protein O1; FKH1; forkhead box protein O1A; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; FKHR; FOXO1A
• Gene ID: 2308
• mRNA Refseq: NM_002015
• Protein Refseq: NP_002006
• MIM: 136533
• UniProt ID: Q12778
• Chromosome Location: 13q14.1
• Pathway: AKT phosphorylates targets in the nucleus, organism-specific biosystem; AKT-mediated inactivation of FOXO1A, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem
• Function: DNA binding, bending; double-stranded DNA binding; protein binding; protein kinase binding; sequence-specific DNA binding; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; transcription factor binding