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Recombinant Human GRM4 Protein

Cat.No. : GRM4-5367H
Product Overview : Human GRM4 full-length ORF (ADR83416.1) recombinant protein without tag.
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  • Gene Information
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Description : L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq
Source : Wheat Germ
Species : Human
Form : Liquid
Molecular Mass : 100.4 kDa
AA Sequence : MPGKRGLGWWWARLPLCLLLSLYGP WMPSSLGKPKGHPHMNSIRIDGDIT LGGLFPVHGRGSEGKPCGELKKEKG IHRLEAMLFALDRINNDPDLLPNIT LGARILDTCSRDTHALEQSLTFVQA LIEKDGTEVRCGSGGPPIITKPERV VGVIGASGSSVSIMVANILRLFKIP QISYASTAPDLSDNSRYDFFSRVVP SDTYQAQAMVDIVRALKWNYVSTVA SEGSYGESGVEAFIQKSREDGGVCI AQSVKIPREPKAGEFDKIIRRLLET SNARAVIIFANEDDIRRVLEAARRA NQTGHFFWMGSDSWGSKIAPVLHLE EVAEGAVTILPKRMSVRGFDRYFSS RTLDNNRRNIWFAEFWEDNFHCKLS RHALKKGSHVKKCTNRERIGQDSAY EQEGKVQFVIDAVYAMGHALHAMHR DLCPGRVGLCPRMDPVDGTQLLKYI RNVNFSGIAGNPVTFNENGDAPGRY DIYQYQLRNDSAEYKVIGSWTDHLH LRIERMHWPGSGQQLPRSICSLPCQ PGERKKTVKGMPCCWHCEPCTGYQY QVDRYTCKTCPYDMRPTENRTGCRP IPIIKLEWGSPWAVLPLFLAVVGIA ATLFVVITFVRYNDTPIVKASGREL SYVLLAGIFLCYATTFLMIAEPDLG TCSLRRIFLGLGMSISYAALLTKTN RIYRIFEQGKRSVSAPRFISPASQL AITFSLISLQLLGICVWFVVDPSHS VVDFQDQRTLDPRFARGVLKCDISD LSLICLLGYSMLLMVTCTVYAIKTR GVPETFNEAKPIGFTMYTTCIVWLA FIPIFFGTSQSADKLYIQTTTLTVS VSLSASVSLGMLYMPKVYIILFHPE QNVPKRKRSLKAVVTAATMSNKFTQ KGNFRPNGEAKSELCENLEAPALAT KQTYVTYTNHAI
Applications : Antibody Production
Functional Study
Compound Screening
Usage : Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 25 mM Tris-HCl of pH8.0 containing 2% glycerol.
Gene Name : GRM4 glutamate receptor, metabotropic 4 [ Homo sapiens ]
Official Symbol : GRM4
Synonyms : GRM4; glutamate receptor, metabotropic 4; metabotropic glutamate receptor 4; GPRC1D; mGlu4; MGLUR4; MGC177594;
Gene ID : 2914
mRNA Refseq : NM_000841
Protein Refseq : NP_000832
MIM : 604100
UniProt ID : Q14833

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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