Recombinant Human HDAC4 Protein, GST-tagged

• Cat.No.: HDAC4-4645H
• Product Overview: Human HDAC4 full-length ORF ( AAH39904.1, 1 a.a. - 972 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 132.8 kDa
• AA Sequence: MLAMKHQQELLEHQRKLERHRQEQE LEKQHREQKLQQLKNKEKGKESAVA STEVKMKLQEFVLNKKKALAHRNLN HCISSDPRYWYGKTQHSSLDQSSPP QSGVSTSYNHPVLGMYDAKDDFPLR KTASEPNLKLRSRLKQKVAERRSSP LLRRKDGPVVTALKKRPLDVTDSAC SSAPGSGPSSPNNSSGSVSAENGIA PAVPSIPAETSLAHRLVAREGSAAP LPLYTSPSLPNITLGLPATGPSAGT AGQQDAERLTLPALQQRLSLFPGTH LTPYLSTSPLERDGGAAHSPLLQHM VLLEQPPAQAPLVTDWYLSGLGALP LHAQSLVGADRVSPSIHKLRQHRPL GRTQSAPLPQNAQALQHLVIQQQHQ QFLEKHKQQFQQQQLQMNKIIPKPS EPARQPESHPEETEEELREHQALLD EPYLDRLPGQKEAHAQAGVQVKQEP IESDEEEAEPPREVEPGQRQPSEQE LLFRQQALLLEQQRIHQLRNYQASM EAAGIPVSFGGHRPLSRAQSSPASA TFPVSVQEPPTKPRFTTGLVYDTLM LKHQCTCGSSSSHPEHAGRIQSIWS RLQETGLRGKCECIRGRKATLEELQ TVHSEAHTLLYGTNPLNRQKLDSKK LLGSLASVFVRLPCGGVGVDSDTIW NEVHSAGAARLAVGCVVELVFKVAT GELKNGFAVVRPPGHHAEESTPMGF CYFNSVAVAAKLLQQRLSVSKILIV DWDVHHGNGTQQAFYSDPSVLYMSL HRYDDGNFFPGSGAPDEVGTGPGVG FNVNMAFTGGLDPPMGDAEYLAAFR TVVMPIASEFAPDVVLVSSGFDAVE GHPTPLGGYNLSARCFGYLTKQLMG LAGGRIVLALEGGHDLTAICDASEA CVSALLGNELDPLPEKVLQQRPNAN AVRSMEKVMEIHSKYWRCLQRTTST AGRSLIEAQTCENEEAETVTAMASL SVGVKPAEKRPDEEPMEEEPPL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: HDAC4 histone deacetylase 4 [ Homo sapiens ]
• Official Symbol: HDAC4
• Synonyms: HDAC4; histone deacetylase 4; HA6116; HD4; HDAC 4; HDAC A; HDACA; KIAA0288; histone deacetylase A; AHO3; BDMR; HDAC-4; HDAC-A
• Gene ID: 9759
• mRNA Refseq: NM_006037
• Protein Refseq: NP_006028
• MIM: 605314
• UniProt ID: P56524