Recombinant Human HEXA Protein, GST-tagged

• Cat.No.: HEXA-4710H
• Product Overview: Human HEXA full-length ORF ( AAH18927, 1 a.a. - 529 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 83.93 kDa
• AA Sequence: MTSSRLWFSLLLAAAFAGRATALWP WPQNFQTSDQRYVLYPNNFQFQYDV SSAAQPGCSVLDEAFQRYRDLLFGS GSWPRPYLTGKRHTLEKNVLVVSVV TPGCNQLPTLESVENYTLTINDDQC LLLSETVWGALRGLETFSQLVWKSA EGTFFINKTEIEDFPRFPHRGLLLD TSRHYLPLSSILDTLDVMAYNKLNV FHWHLVDDPSFPYESFTFPELMRKG SYNPVTHIYTAQDVKEVIEYARLRG IRVLAEFDTPGHTLSWGPGIPGLLT PCYSGSEPSGTFGPVNPSLNNTYEF MSTFFLEVSSVFPDFYLHLGGDEVD FTCWKSNPEIQDFMRKKGFGEDFKQ LESFYIQTLLDIVSSYGKGYVVWQE VFDNKVKIQPDTIIQVWREDIPVNY MKELELVTKAGFRALLSAPWYLNRI SYGPDWKDFYVVEPLAFEGTPEQKA LVIGGEACMWGEYVDNTNLVPRLWP RAGAVAERLWSNKLTSDLTFAYERL SHFRCELLRRGVQAQPLNVGFCEQE FEQT
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: HEXA hexosaminidase A (alpha polypeptide) [ Homo sapiens ]
• Official Symbol: HEXA
• Synonyms: HEXA; hexosaminidase A (alpha polypeptide); beta-hexosaminidase subunit alpha; GM2 gangliosidosis; Tay Sachs disease; hexosaminidase subunit A; beta-N-acetylhexosaminidase subunit alpha; N-acetyl-beta-glucosaminidase subunit alpha; TSD; MGC99608
• Gene ID: 3073
• mRNA Refseq: NM_000520
• Protein Refseq: NP_000511
• MIM: 606869
• UniProt ID: P06865