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Recombinant Human HOGA1 Protein, MYC/DDK-tagged

Cat.No. : HOGA1-1844H
Product Overview : Recombinant human HOGA1 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
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  • Gene Information
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Description : The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 35.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 [ Homo sapiens (human) ]
Official Symbol : HOGA1
Synonyms : C10orf65; DHDPS2; DHDPSL; HP3; NPL2
Gene ID : 112817
mRNA Refseq : NM_001134670.1
Protein Refseq : NP_001009997.2
MIM : 613597
UniProt ID : Q86XE5.1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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