| Description : |
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq |
| Source : |
Wheat Germ |
| Species : |
Human |
| Form : |
Liquid |
| Molecular Mass : |
55.8 kDa |
| AA Sequence : |
MSLPNSSCLLEDKMCEGNKTTMASP QLMPLVVVLSTICLVTVGLNLLVLY AVRSERKLHTVGNLYIVSLSVADLI VGAVVMPMNILYLLMSKWSLGRPLC LFWLSMDYVASTASIFSVFILCIDR YRSVQQPLRYLKYRTKTRASATILG AWFLSFLWVIPILGWNHFMQQTSVR REDKCETDFYDVTWFKVMTAIINFY LPTLLMLWFYAKIYKAVRQHCQHRE LINRSLPSFSEIKLRPENPKGDAKK PGKESPWEVLKRKPKDAGGGSVLKS PSQTPKEMKSPVVFSQEDDREVDKL YCFPLDIVHMQAAAEGSSRDYVAVN RSHGQLKTDEQGLNTHGASEISEDQ MLGDSQSFSRTDSDTTTETAPGKGK LRSGSNTGLDYIKFTWKRLRSHSRQ YVSGLHMNRERKAAKQLGFIMAAFI LCWIPYFIFFMVIAFCKNCCNEHLH MFTIWLGYINSTLNPLIYPLCNENF KKTFKRILHIRS |
| Applications : |
Antibody Production
Functional Study
Compound Screening |
| Usage : |
Heating may cause protein aggregation. Please do not heat this product before electrophoresis. |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
