Recombinant Human HSPA8 protein, His/MBP-tagged
Cat.No. : | HSPA8-274H |
Product Overview : | Recombinant Human HSPA8(419-601 aa) fused with His/MBP tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Source : | E. coli |
Species : | Human |
Tag : | His/MBP |
Form : | Liquid in PBS |
Protein length : | 419-601 aa |
Purity : | SDS-PAGE >90% |
Applications : | WB Positive Control |
Stability : | Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | HSPA8 heat shock 70kDa protein 8 [ Homo sapiens ] |
Official Symbol : | HSPA8 |
Synonyms : | HSPA8; heat shock 70kDa protein 8; heat shock 70kD protein 8 , HSPA10; heat shock cognate 71 kDa protein; HSC70; HSC71; HSP73; LPS-associated protein 1; heat shock 70kd protein 10; heat shock cognate protein 54; constitutive heat shock protein 70; lipopolysaccharide-associated protein 1; N-myristoyltransferase inhibitor protein 71; LAP1; HSC54; HSP71; NIP71; HSPA10; MGC29929; MGC131511; |
Gene ID : | 3312 |
mRNA Refseq : | NM_006597 |
Protein Refseq : | NP_006588 |
MIM : | 600816 |
UniProt ID : | P11142 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionHSPA8 is a central player in the heat shock response, assisting in the refolding of denatured proteins. It modulates downstream pathways such as HSF1 activation, orchestrating a cellular survival response.
HSPA8 plays a role in neurodegenerative diseases, mitigating protein aggregation and neuronal dysfunction. Its chaperone activity is crucial for maintaining protein homeostasis in the nervous system.
HSPA8 exhibits anti-apoptotic functions by interacting with pro-apoptotic proteins and preventing their activation. Its role in apoptosis regulation contributes to cell survival during stress.
HSPA8 is involved in autophagy, facilitating the clearance of misfolded proteins and damaged organelles. It interacts with autophagy receptors, promoting their recognition by autophagosomes.
HSPA8 participates in antigen presentation and modulates immune cell functions. It chaperones antigens for presentation on major histocompatibility complexes, influencing immune recognition and response.
Customer Reviews (3)
Write a reviewThe lab product's precision and quality are noteworthy.
The customer service team was accommodating, and the delivery exceeded my expectations.
This lab product is synonymous with excellence.
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