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Recombinant Human HSPA8 protein, His/MBP-tagged

Cat.No. : HSPA8-274H
Product Overview : Recombinant Human HSPA8(419-601 aa) fused with His/MBP tag was expressed in E. coli.
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Description : This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : His/MBP
Form : Liquid in PBS
Protein length : 419-601 aa
Purity : SDS-PAGE >90%
Applications : WB Positive Control
Stability : Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage : Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : HSPA8 heat shock 70kDa protein 8 [ Homo sapiens ]
Official Symbol : HSPA8
Synonyms : HSPA8; heat shock 70kDa protein 8; heat shock 70kD protein 8 , HSPA10; heat shock cognate 71 kDa protein; HSC70; HSC71; HSP73; LPS-associated protein 1; heat shock 70kd protein 10; heat shock cognate protein 54; constitutive heat shock protein 70; lipopolysaccharide-associated protein 1; N-myristoyltransferase inhibitor protein 71; LAP1; HSC54; HSP71; NIP71; HSPA10; MGC29929; MGC131511;
Gene ID : 3312
mRNA Refseq : NM_006597
Protein Refseq : NP_006588
MIM : 600816
UniProt ID : P11142

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In the context of cellular stress, how does HSPA8 contribute to the heat shock response, and what downstream signaling pathways does it modulate to promote cell survival? 03/14/2022

HSPA8 is a central player in the heat shock response, assisting in the refolding of denatured proteins. It modulates downstream pathways such as HSF1 activation, orchestrating a cellular survival response.

Can you discuss the involvement of HSPA8 in neurodegenerative diseases, and how does its chaperone activity influence protein aggregation and neuronal dysfunction? 10/03/2021

HSPA8 plays a role in neurodegenerative diseases, mitigating protein aggregation and neuronal dysfunction. Its chaperone activity is crucial for maintaining protein homeostasis in the nervous system.

How does HSPA8 participate in the regulation of apoptosis, and what anti-apoptotic mechanisms does it employ to maintain cellular viability under stress conditions? 04/11/2020

HSPA8 exhibits anti-apoptotic functions by interacting with pro-apoptotic proteins and preventing their activation. Its role in apoptosis regulation contributes to cell survival during stress.

What is the significance of HSPA8 in autophagy, and how does it influence the selective degradation of misfolded proteins and damaged organelles? 09/27/2019

HSPA8 is involved in autophagy, facilitating the clearance of misfolded proteins and damaged organelles. It interacts with autophagy receptors, promoting their recognition by autophagosomes.

What are the mechanisms by which HSPA8 regulates the immune response, particularly its involvement in antigen presentation and the modulation of immune cell functions? 07/22/2018

HSPA8 participates in antigen presentation and modulates immune cell functions. It chaperones antigens for presentation on major histocompatibility complexes, influencing immune recognition and response.

Customer Reviews (3)

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Reviews
12/01/2021

    The lab product's precision and quality are noteworthy.

    10/25/2020

      The customer service team was accommodating, and the delivery exceeded my expectations.

      05/10/2018

        This lab product is synonymous with excellence.

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