Recombinant Human IKBKB protein, GST-tagged
Cat.No. : | IKBKB-125H |
Product Overview : | Recombinant Human IKBKB(1-662 aa) fused with GST tag at N-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | IKKβ is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. The activity of IKKβ is stimulated by TNF and IL1 and IKKβ forms a heterodimer that interacts with NIK. Overex |
Source : | Insect cells |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~105 kDa |
Purity : | >95% |
Applications : | Kinase Assay, Western Blot |
Stability : | 1 year at - 70 centigrade from the date of shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name : | IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [ Homo sapiens ] |
Official Symbol : | IKBKB |
Synonyms : | IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; IKK beta; IKK2; IKKB; NFKBIKB; IKK-B; I-kappa-B kinase 2; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta; IKK-beta; FLJ33771; FLJ36218; FLJ38368; FLJ40509; MGC131801; |
Gene ID : | 3551 |
mRNA Refseq : | NM_001190720 |
Protein Refseq : | NP_001177649 |
MIM : | 603258 |
UniProt ID : | O14920 |
Chromosome Location : | 8p11.2 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; |
Function : | ATP binding; IkappaB kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
IKBKB-2046R | Recombinant Rhesus Macaque IKBKB Protein, His (Fc)-Avi-tagged | +Inquiry |
IKBKB-87H | Recombinant Human IKBKB Protein, His-tagged | +Inquiry |
IKBKB-1064H | Recombinant Human IKBKB Protein (S695-S756), Tag Free | +Inquiry |
IKBKB-1065H | Recombinant Human IKBKB Protein (S695-S756), GST tagged | +Inquiry |
IKBKB-1162H | Recombinant Human IKBKB Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IKBKB-849HCL | Recombinant Human IKBKB cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionIKBKB protein is a key regulator of the NF-κB pathway, which plays a central role in the inflammatory response. Dysregulation of IKBKB can contribute to the development of inflammatory diseases.
Yes, dysregulation of IKBKB protein and the NF-κB pathway has been implicated in neuroinflammation and the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
Yes, targeting IKBKB protein or the NF-κB pathway is being explored as a potential strategy for treating autoimmune diseases by modulating the inflammatory response.
IKBKB protein activates the NF-κB pathway, which can promote cell survival and inhibit apoptosis in response to various stimuli, making it a potential target for cancer therapy.
Yes, mutations in the IKBKB gene have been associated with immunodeficiency disorders and inflammatory diseases, highlighting the importance of IKBKB protein in immune system function.
Customer Reviews (3)
Write a reviewTheir team of experts is readily available to assist you with any inquiries or challenges you may encounter during your experiments.
Its purity and functional integrity guarantee optimal performance in a wide range of experimental applications.
This protein, manufactured with utmost precision, provides reliable and consistent results, ensuring the accuracy and reproducibility of your research findings.
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