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Recombinant Human IL17C protein, His-tagged

Cat.No. : IL17C-149H
Product Overview : Recombinant Human IL17C(Cys36~Val187) fused with His tag at N-terminal was expressed in E. coli.
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Description : The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells.
Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300
Molecular Mass : 20.7kDa
Protein length : Cys36~Val187
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : > 95%
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others.
Gene Name : IL17C interleukin 17C [ Homo sapiens ]
Official Symbol : IL17C
Synonyms : IL17C; interleukin 17C; interleukin-17C; CX2; IL 17C; IL 21; MGC126884; MGC138401; cytokine CX2; IL-21; IL-17C;
Gene ID : 27189
mRNA Refseq : NM_013278
Protein Refseq : NP_037410
MIM : 604628
UniProt ID : Q9P0M4
Chromosome Location : 16q24
Function : cytokine activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How is the involvement of IL17C in autoimmune diseases elucidated using experimental models and patient samples? 12/05/2022

Animal models, patient biopsies, and genetic association studies reveal IL17C's role in autoimmune diseases.

Can you explain the experimental designs used to study the crosstalk between IL17C and other cytokines in inflammatory responses? 06/30/2022

Combination cytokine stimulation assays and signaling pathway inhibitors elucidate IL17C's crosstalk.

How is the function of IL17C in promoting tumor growth and progression investigated in cancer models? 06/05/2022

Xenograft models and tumor growth measurements uncover IL17C's contribution to cancer progression.

How are the effects of IL17C modulation on specific immune cell populations characterized using flow cytometry and cell sorting? 01/18/2022

Flow cytometry analysis with cell-specific markers characterizes IL17C's impact on immune cell subsets.

What molecular techniques are utilized to validate the therapeutic potential of targeting IL17C in inflammatory disorders? 01/10/2022

Neutralizing antibodies and RNA interference validate IL17C's potential as a therapeutic target.

What approaches are taken to assess the role of IL17C in mucosal immunity and host defense against infections? 11/15/2021

Infection models, bacterial challenges, and mucosal sampling assess IL17C's role in host defense.

Could you elaborate on the methods used to study IL17C's contribution to tissue-specific immune cell recruitment? 04/29/2021

Chemotaxis assays and confocal microscopy study IL17C-mediated immune cell recruitment.

What strategies are used to explore the impact of IL17C on epithelial barrier integrity and inflammation? 10/26/2018

Organoid culture systems and cytokine measurements explore IL17C's impact on epithelial barrier function.

What experimental techniques are employed to investigate the binding partners of IL17C and its downstream signaling pathways? 12/21/2017

Co-immunoprecipitation and mass spectrometry identify IL17C interactors and signaling molecules.

How do researchers differentiate the functional roles of IL17C from other IL17 family members in immune responses? 04/10/2017

Comparative functional assays and gene knockout models distinguish IL17C's unique roles.

Customer Reviews (3)

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Reviews
11/26/2021

    High purity levels.

    03/26/2021

      Potent in anti-fungal assays.

      06/07/2020

        Suitable for receptor binding studies.

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