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Active Recombinant Human IL17RA protein, Fc-tagged

Cat.No. : IL17RA-373H
Product Overview : Recombinant Human IL17RA Protein(NP_055154.3)(Leu 33 - Trp 320), fused with a Fc tag, is expressed from human 293 cells (HEK293).
  • Specification
  • Gene Information
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Source : HEK293
Species : Human
Tag : Fc
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.
Bio-activity : Immobilized Human IL-17F, His Tag at 2 μg/mL (100 μL/well) can bind Human IL-17 RA, Fc Tag with a linear range of 5-156 ng/mL.
Molecular Mass : The protein has a calculated MW of 60.1 kDa. The protein migrates as 71-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein Length : Leu 33 - Trp 320
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : IL17RA interleukin 17 receptor A [ Homo sapiens ]
Official Symbol : IL17RA
Synonyms : IL17RA; interleukin 17 receptor A; IL17R, interleukin 17 receptor; interleukin-17 receptor A; CD217; CDw217; hIL 17R; IL 17RA; IL-17 receptor A; IL17R; CANDF5; IL-17RA; hIL-17R; FLJ32274; FLJ36453; MGC10262;
Gene ID : 23765
mRNA Refseq : NM_014339
Protein Refseq : NP_055154
MIM : 605461
UniProt ID : Q96F46

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What experimental techniques are employed to investigate the interaction between IL17RA and various IL17 family members, and how is their binding specificity determined? 12/02/2022

Surface plasmon resonance, co-immunoprecipitation, and mutagenesis studies reveal IL17RA's binding partners and affinity.

Can you discuss the experimental designs used to examine the crosstalk between IL17RA signaling and other immune pathways, such as TNF-α or IFN-纬 pathways? 11/16/2020

Cross-pathway signaling assays, gene expression profiling, and functional rescue experiments unveil IL17RA's interaction networks.

What strategies are utilized to explore the contribution of IL17RA to tissue remodeling processes, such as angiogenesis and fibrosis? 11/08/2020

Angiogenesis assays, fibroblast activation assays, and tissue remodeling models illuminate IL17RA's role in tissue repair.

How is the potential of IL17RA as a therapeutic target evaluated in experimental settings, and what challenges exist in translating these findings to clinical applications? 03/15/2020

Animal models, pharmacological interventions, and toxicity assessments evaluate IL17RA-targeted therapies and translational challenges.

How do researchers study the involvement of IL17RA in autoimmune disorders through patient samples, and what insights have been gained? 12/26/2019

Patient cohorts, clinical data analysis, and immune profiling provide insights into IL17RA's relevance in autoimmune diseases.

How do researchers study the role of IL17RA in the regulation of immune cell recruitment and infiltration in inflammatory tissues? 12/13/2018

Flow cytometry, in vivo imaging, and chemotaxis assays characterize immune cell responses guided by IL17RA activation.

Can you elaborate on the methods used to dissect the intracellular signaling pathways triggered by IL17RA activation, especially in the context of autoimmune diseases? 04/28/2018

Phosphorylation assays, gene expression analysis, and knockout models dissect IL17RA-mediated signaling cascades.

Could you explain the experimental approaches employed to assess the impact of IL17RA inhibition on chronic inflammatory diseases in preclinical models? 01/10/2018

Disease models, antibody-based treatments, and inflammatory biomarker assessments elucidate IL17RA's therapeutic potential.

What molecular methods are employed to understand the genetic and epigenetic regulation of IL17RA expression in immune cells? 07/22/2017

ChIP-sequencing, promoter analysis, and epigenetic modification studies uncover IL17RA gene regulation mechanisms.

What techniques are used to investigate the role of IL17RA in maintaining epithelial barrier integrity and preventing microbial invasion? 03/06/2017

Epithelial barrier assays, microbiome analysis, and infection models decipher IL17RA's role in mucosal defense.

Customer Reviews (3)

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Reviews
01/23/2021

    Effective in T-cell activation.

    07/12/2019

      Suitable for co-immunoprecipitation.

      03/17/2017

        High solubility.

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