Recombinant Human IL18RAP Protein, Fc-tagged
Cat.No. : | IL18RAP-194H |
Product Overview : | Recombinant human IL18RAP (NP_003844.1) (Met 1-Gly 357) was fused with the Fc region of human IgG1 at the C-terminus. |
- Specification
- Gene Information
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Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Predicted N Terminal : | Phe 20 |
Form : | Lyophilized from sterile PBS, pH 7.4, 5%~8% trehalose and mannitol. |
Molecular Mass : | The recombinant human IL18RAP/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 575 amino acids and has a calculated molecular mass of 65.2 kDa. As a result of glycosylation, the apparent molecular mass of rhIL18RAP/Fc monomer is approximately 80-90 kDa in reduced SDS-PAGE. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >95 % as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | IL18RAP interleukin 18 receptor accessory protein [ Homo sapiens ] |
Official Symbol : | IL18RAP |
Synonyms : | IL18RAP; interleukin 18 receptor accessory protein; interleukin-18 receptor accessory protein; AcPL; CD218b; IL-1R7; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta; IL-18 receptor beta; interleukin-1 receptor 7; interleukin-18 receptor beta; IL-18 receptor accessory protein; CD218 antigen-like family member B; ACPL; IL18RB; CDw218b; MGC120589; MGC120590; |
Gene ID : | 8807 |
mRNA Refseq : | NM_003853 |
Protein Refseq : | NP_003844 |
MIM : | 604509 |
UniProt ID : | O95256 |
Chromosome Location : | 2q12.1 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL12 signaling mediated by STAT4, organism-specific biosystem; IL12-mediated signaling events, organism-specific biosystem; IL23-mediated signaling events, organism-specific biosystem; |
Products Types
◆ Recombinant Protein | ||
IL18RAP-157H | Recombinant Human IL18RAP Protein, His-tagged | +Inquiry |
IL18RAP-17H | Recombinant Human IL18RAP Protein, hIgG/His-tagged | +Inquiry |
IL18RAP-97H | Recombinant Human IL18RAP Protein, His (Fc)-Avi-tagged | +Inquiry |
IL18RAP-922M | Active Recombinant Mouse IL18RAP Protein, His-tagged | +Inquiry |
IL18RAP-59C | Recombinant Cynomolgus IL18RAP Protein, hFc-tagged | +Inquiry |
◆ Lysates | ||
IL18RAP-001MCL | Recombinant Mouse IL18RAP cell lysate | +Inquiry |
IL18RAP-1353CCL | Recombinant Cynomolgus IL18RAP cell lysate | +Inquiry |
IL18RAP-2602HCL | Recombinant Human IL18RAP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionRT-qPCR, immunohistochemistry, and single-cell RNA sequencing characterize IL18RAP expression levels and regulation in diverse cellular contexts.
Animal models, patient samples, and therapeutic interventions elucidate IL18RAP's involvement in immune-related disorders and its potential as a therapeutic target.
Isoform-specific knockdown, mutagenesis, and functional assays delineate IL18RAP isoforms' distinct roles in modulating IL18-mediated responses.
Co-immunoprecipitation assays, FRET studies, and biophysical techniques characterize IL18RAP's interactions with IL18 and IL18R1 partners.
Mass spectrometry, mutagenesis, and functional assays investigate the impact of post-translational modifications on IL18RAP's conformation and function.
Surface plasmon resonance, bio-layer interferometry, and surface plasmon-enhanced fluorescence assays quantify IL18RAP's binding kinetics to IL18 and IL18R1.
siRNA knockdown, CRISPR/Cas9-mediated knockout, and transgenic models unravel IL18RAP's physiological roles and contributions to IL18 signaling.
Single-molecule imaging, super-resolution microscopy, and live-cell imaging visualize the dynamic assembly of IL18 receptor complexes involving IL18RAP.
X-ray crystallography, NMR spectroscopy, and computational modeling reveal IL18RAP's structural interactions with IL18 and IL18R1 domains.
Phosphoprotein analysis, pathway-specific inhibitors, and functional assays dissect IL18RAP's intracellular signaling cascades and its crosstalk with IL18R1.
Customer Reviews (3)
Write a reviewEffective in signaling studies.
High specificity.
Reliable in co-immunoprecipitation.
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