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Active Recombinant Human IL4R protein, His-tagged

Cat.No. : IL4R-587H
Product Overview : Recombinant Human IL4R protein (Met 1-His 232), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293).
  • Specification
  • Gene Information
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Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from sterile PBS, pH 7.4
Bio-activity : 1. Measured by its binding ability in a functional ELISA. Immobilized human IL4R-His at 10 μg/mL (100 μl/well) can bind biotinylated human IL4. The EC50 of biotinylated human IL4 is 20.8-48.5 ng/mL.
2. Measured by its ability to inhibit IL-4 dependent proliferation of TF-1 human erthroleukemic cells. The ED50 for this effect is 2-10 ng/mL in the presence of 0.2 ng/ml IL-4.
Molecular Mass : The secreted recombinant human IL4R consists of 218 amino acids after cleavage of the signal peptide and predictes a molecular mass of 25.18 kDa. In SDS-PAGE under reducing conditions, it migrates with the apparent molecular mass of 43-48 kDa due to glycosylation.
Protein Length : Met 1-His 232
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 98 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : IL4R interleukin 4 receptor [ Homo sapiens ]
Official Symbol : IL4R
Synonyms : IL4R; interleukin 4 receptor; interleukin-4 receptor subunit alpha; CD124; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain; IL4RA; IL-4RA;
Gene ID : 3566
mRNA Refseq : NM_000418
Protein Refseq : NP_000409
MIM : 147781
UniProt ID : P24394

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How about function of IL4R? 10/15/2022

IL4R is a synthetic protein that mimics the IL-4 signaling pathway in nature and binds to the IL-4 receptor in cells, which can be used to study the IL-4 signaling pathway and related diseases.

What is the production technology of IL4R? 02/23/2022

Common IL4R production technologies include prokaryotic expression systems and mammalian cell expression systems.

Which application of IL4R in tumor therapy? 01/26/2022

This protein is used in tumor immunotherapy, which can promote anti-tumor immune response and enhance the anti-tumor effect of cytotoxic T lymphocytes.

In what fields does IL4R have applications? 07/09/2021

It is mainly used in immunology, drug research and other fields. It is also widely used in vaccines, biotechnology, cancer treatment and so on.

Are there have application of IL4R in the treatment of asthma? 03/23/2021

IL4R is used to treat severe pheochromocytome-induced aerodoritis and was approved by the FDA as the first drug to treat this disease.

Can IL4R be administered orally? 05/08/2020

IL4R cannot generally be administered orally, and needs to be administered by injection or intravenous drip.

Customer Reviews (3)

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Reviews
06/30/2022

    Easy to attach to the surface of cells or materials.

    09/29/2021

      It has growth factor activity to promote cell growth and proliferation.

      02/27/2019

        In animals or humans caused by the prone production of antibodies.

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