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Recombinant Human IL7R Protein, GST-tagged

Cat.No. : IL7R-5168H
Product Overview : Human IL7R full-length ORF ( AAH67539.1, 1 a.a. - 459 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 77.9 kDa
AA Sequence : MTILGTTFGMVFSLLQVVSGESGYA QNGDLEDAELDDYTFSCYSQLEVNG SQHSLTCAFEDPDVNTTNLEFEICG ALVEVKCLNFRKLQEIYFIETKKFL LIGKSNICVKVGEKSLTCKKIDLTT IVKPEAPFDLSVIYREGANDFVVTF NTSHLQKKYVKVLMHDVAYRQEKDE NKWTHVNLSSTKLTLLQRKLQPAAM YEIKVRSIPDHYFKGFWSEWSPSYY FRTPEINNSSGEMDPILLTISILSF FSVALLVILACVLWKKRIKPIVWPS LPDHKKTLEHLCKKPRKNLNVSFNP ESFLDCQIHRVDDIQARDEVEGFLQ DTFPQQLEESEKQRLGGDVQSPNCP SEDVVITPESFGRDSSLTCLAGNVS ACDAPILSSSGSLDCRESGKNGPHV YQDLLLSLGTTNSTLPPPFSLQSGI LTLNPVAQGQPILTSLGSNQEEAYV TMSSFYQNQ
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : IL7R interleukin 7 receptor [ Homo sapiens ]
Official Symbol : IL7R
Synonyms : IL7R; interleukin 7 receptor; interleukin-7 receptor subunit alpha; CD127; IL-7RA; CD127 antigen; IL-7R subunit alpha; IL-7 receptor subunit alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; ILRA; IL7RA; CDW127; IL-7R-alpha;
Gene ID : 3575
mRNA Refseq : NM_002185
Protein Refseq : NP_002176
MIM : 146661
UniProt ID : P16871

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the prospect of recombinant IL7R in tumor immunotherapy? 11/19/2022

IL7R is a potential drug for tumor immunotherapy, which is expected to enhance anti-tumor immune response, but further research and clinical demonstration are still needed.

Is there any research showing that recombinant IL7R can be used to treat immune system failure? 09/23/2022

Recombinant IL7R can enhance the body's immune response, but there is not enough evidence to show that it can be used to treat immune system failure.

How the role of IL7R in immunotherapy? 05/05/2022

It can enhance the immune response ability of T cells and improve the immune response of the body, so as to have a therapeutic effect on immune-related diseases.

Does IL7R have synergistic effects with immune checkpoint inhibitors? 04/20/2022

There is no clear evidence that IL7R has a synergistic effect with immune checkpoint inhibitors, but this research direction deserves further exploration.

Which diseases is IL7R associated with? 08/03/2020

IL7R has been associated with immune-related diseases such as cancer, inflammatory bowel disease, and rheumatoid arthritis.

Is there any restriction on the use of IL7R? 10/13/2019

The use of IL7R is patient specific and may be subject to some limitations, such as pregnant and lactating women and patients with certain immune-related diseases.

Customer Reviews (3)

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Reviews
02/21/2022

    The pharmacodynamic parameters of IL7R were good.

    02/01/2022

      IL7R has good compatibility and stability with various excipients.

      09/30/2021

        Strong potential to desensitize specific allergens.

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