Recombinant Human IRF4 Protein, GST-His-tagged

• Cat.No.: IRF4-726H
• Product Overview: Recombinant Human IRF4, transcript variant 1, fused with N-terminal GST and C-terminal His was expressed in E. coli.

Specification

• Description: The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: GST-His
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
• Molecular Mass: 79.6kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: IRF4 interferon regulatory factor 4 [ Homo sapiens ]
• Official Symbol: IRF4
• Synonyms: IRF4; interferon regulatory factor 4; MUM1; LSIRF; multiple myeloma oncogene 1; lymphocyte-specific interferon regulatory factor; NF-EM5
• Gene ID: 3662
• mRNA Refseq: NM_001195286
• Protein Refseq: NP_001182215
• MIM: 601900
• UniProt ID: Q15306