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Recombinant Human ITGA5 protein, His & GST-tagged

Cat.No. : ITGA5-6771H
Product Overview : Recombinant Human ITGA5 aa. (Glu895~Ala1049 (Accession # P08648)) fused with N-terminal His & GST tag was produced in E. coli cells.
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  • Gene Information
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Description : The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
Source : E. coli
Species : Human
Tag : His & GST
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 50.0kDa.
Protein length : Glu895~Ala1049 (Accession # P08648)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 8.4.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
Reconstitution : Reconstitute in sterile ddH2O.
Gene Name : ITGA5 integrin subunit alpha 5 [ Homo sapiens (human) ]
Official Symbol : ITGA5
Synonyms : FNRA; CD49e; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronectin receptor, alpha polypeptide; fibronectin receptor, alpha subunit; integrin alpha-F; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); very late activation protein 5, alpha subunit; integrin alpha-5
Gene ID : 3678
mRNA Refseq : NM_002205.4
Protein Refseq : NP_002196.4
UniProt ID : P08648

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does ITGA5 interact with other components of the extracellular matrix? 10/12/2022

ITGA5 works with extracellular matrix components, regulating cell-matrix interactions.

What is the impact of altered ITGA5 activity on wound healing? 05/03/2020

Altered ITGA5 activity can impact wound healing and tissue repair processes.

How do genetic variations in ITGA5 affect cell function? 04/14/2020

Genetic mutations in ITGA5 can lead to impaired cell adhesion and migration, affecting tissue integrity.

What is the primary role of ITGA5 in cell adhesion? 03/01/2020

ITGA5, an integrin, is crucial for cell adhesion, facilitating cells' attachment to the extracellular matrix.

What role does ITGA5 play in tissue remodeling? 12/21/2018

ITGA5 is involved in tissue remodeling, aiding in the reorganization and repair of tissues.

What potential therapeutic applications arise from targeting ITGA5 in regenerative medicine? 02/15/2018

Targeting ITGA5 could offer new strategies for enhancing tissue repair and regeneration in various medical conditions.

How does ITGA5 contribute to cell migration? 04/04/2017

It plays a key role in cell migration, essential for processes like wound healing and tissue formation.

Customer Reviews (3)

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Reviews
10/15/2022

    Outstanding accuracy, accelerates research progress.

    08/02/2021

      Efficient service, essential for research outcomes.

      03/15/2021

        Trusted for research integrity, an invaluable research asset.

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