"KMT2E" Related Products

Recombinant Human KMT2E protein, GST-tagged, Active

Cat.No.: KMT2E-192H
Product Overview: Recombinant Human KMT2E(1-548 aa) fused with GST tag at N-terminal was expressed in Insect cells.
Description: Mixed-lineage leukemia protein 5 (MLL5) plays a key regulatory role in hematopoiesis by mediating mono- or demethylation of lysine-4 of histone H3. MLL5 can associate with host cell factor-1 (HCF-1) and be recruited to E2F1-responsive promoters, and thus promotes cell cycle progression. Isoform NKp44L acts as cellular ligand for a natural cytotoxicity receptor, which is critical for NK cell-mediated innate immunity.
Source: Insect cells
Species: Human
Tag : GST
Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 250 nmol/min/mg
Molecular Mass: 100 kDa
Protein length: 1-548 aa
Purity: >90%
Applications: Methyltransferase Assay
Stability: 1 year at -70 centigrade from the date of shipment
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: KMT2E lysine methyltransferase 2E [ Homo sapiens ]
Official Symbol: KMT2E
Synonyms: MLL5; NKp44L; HDCMC04P; histone-lysine N-methyltransferase MLL5; lysine (K)-specific methyltransferase 2E; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia protein 5
Gene ID: 55904
mRNA Refseq: NM_182931
Protein Refseq: NP_891847
UniProt ID: Q8IZD2
Chromosome Location: 7q22.3
Pathway: Chromatin modifying enzymes, organism-specific biosystem; Lysine degradation, organism-specific biosystem; PKMTs methylate histone lysines, organism-specific biosystem
Function: enzyme binding; transcription coactivator activity; zinc ion binding
Products Types

◆ Lysates

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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