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Recombinant Human LAMP2 protein, His & GST-tagged

Cat.No. : LAMP2-6992H
Product Overview : Recombinant Human LAMP2 aa. (Lys193~Asn375 (Accession # P13473)) fused with N-terminal His & GST tag was produced in E. coli cells.
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  • Gene Information
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Description : The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins.
Source : E. coli
Species : Human
Tag : His & GST
Form : Freeze-dried powder
Molecular Mass : 50kDa as determined by SDS-PAGE reducing conditions.
Protein length : Lys193~Asn375 (Accession # P13473)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 6.4.
Applications : Positive Control; Immunogen; SDS-PAGE; WB
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Concentration : 200ug/mL
Storage buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : LAMP2 lysosomal associated membrane protein 2 [ Homo sapiens (human) ]
Official Symbol : LAMP2
Synonyms : LAMP2; lysosomal associated membrane protein 2; LAMPB; CD107b; LAMP-2; LGP-96; LGP110; lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B
Gene ID : 3920
mRNA Refseq : NM_001122606.1
Protein Refseq : NP_001116078.1
UniProt ID : P13473

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does LAMP2 protein function in the context of cardiovascular diseases? 06/10/2022

LAMP2 may play a role in maintaining cardiac function and the clearance of damaged organelles in the heart, making it relevant to cardiovascular diseases.

How are mutations in the LAMP2 gene detected in clinical practice? 05/01/2022

Mutations in the LAMP2 gene can be identified through genetic testing, such as DNA sequencing.

What are the potential therapeutic implications of targeting LAMP2 in Danon disease? 04/25/2022

Targeting LAMP2 function or expression may represent a potential therapeutic strategy for treating Danon disease and other lysosomal storage disorders.

What are the clinical implications of LAMP2 deficiency? 02/08/2018

LAMP2 deficiency has been associated with Danon disease, a rare genetic disorder characterized by cardiomyopathy, skeletal myopathy, and intellectual disability.

How is LAMP2 protein involved in lysosomal function? 05/25/2017

LAMP2 is involved in maintaining the integrity and stability of lysosomal membranes, as well as facilitating the fusion of lysosomes with autophagosomes during autophagy.

Customer Reviews (3)

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Reviews
12/20/2021

    LAMP2 is extensively used in protein electron microscopy structure analysis due to its compatibility with this technique, providing crucial insights into molecular architectures.

    12/11/2017

      One aspect that sets the LAMP2 Protein apart is the excellent technical support provided by the manufacturer.

      08/07/2016

        I have found the LAMP2 Protein to be highly stable, enabling long-term experiments without compromising its performance.

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