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Active Recombinant Human LIFR Protein, Fc-tagged

Cat.No. : LIFR-044H
Product Overview : Recombinant human Leukemia inhibitory factor receptor Fc Chimera (rhLIFR-Fc) contain NP_001121143 over Met 1 - Ser 833 positions, which was expressed in human 293 cells (HEK293).
  • Specification
  • Gene Information
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Description : This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Source : HEK293 cells
Species : Human
Tag : Fc
Bio-activity : Measured by its ability to inhibit LIF dependent proliferation of TF1 human erythroleukemic cells. The ED50 for this effect is typically 3-10 µg/mL in the presence of 4 ng/mL of recombinant human LIF.
Molecular Mass : rhLIFR-Fc was fused with the Fc region of human IgG1 at the C-terminus, The reduced monomer has a calculated molecular mass of 115.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhLIFR-Fc monomer is approximately 135-150 kDa due to the glycosylation.
Endotoxin : Less than 0.01 ng endotoxin/ 1 µg rhLIFR-Fc.
Purity : >96% purity as determined by SDS-PAGE of reduced rhLIFR-Fc.
Notes : Research Use Only. Not for use in diagnostic or therapeutic procedures.
Storage : Store at -20 centigrade in lyophilized state after receipt. For long term storage, upon reconstitution rhLIFR-Fc should be aliquot and store at -20 centigrade or -8 centigrade centigrade. Avoid repeated freeze-thaw cycles.
Storage Buffer : Bulk protein in a 0.22 µm filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder. Normally 2-8% trehalose and mannitol are added as protectants before lyophilization.
Gene Name : LIFR leukemia inhibitory factor receptor alpha [ Homo sapiens ]
Official Symbol : LIFR
Synonyms : LIFR; leukemia inhibitory factor receptor alpha; leukemia inhibitory factor receptor; CD118; LIF receptor; CD118 antigen; SWS; SJS2; STWS; LIF-R; FLJ98106; FLJ99923;
Gene ID : 3977
mRNA Refseq : NM_001127671
Protein Refseq : NP_001121143
MIM : 151443
UniProt ID : P42702

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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