Active Recombinant Human LILRA1 protein, His-tagged
Cat.No. : | LILRA1-267H |
Product Overview : | Recombinant Human LILRA1(Pro17-Asn461) fused with His tag at C-terminal was expressed in NS0. |
- Specification
- Gene Information
- Related Products
Description : | LILRA1, also known as CD85i and LIR-6, is an approximately 70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA1 consists of a 445 amino acid (aa) extracellular domain (ECD) with 4 Ig-like domains, a 21 aa transmembrane segment, and a 7 aa cytoplasmic tail. The transmembrane segment contains a positively charged arginine which may mediate association with signaling molecules. Alternative splicing generates an isoform that lacks the third and fourth Ig-like domains. LILRA1 is expressed on monocytes and binds to the free heavy chain of the MHC class I molecule HLA-B27. It is activated in response to the BCG mycobacterial strain. R&D Systems in-house testing indicates that LILRA1 binds to Angiopoietin-like 7, consistent with the demonstrated functional interactions between other members of these protein families. |
Source : | Mammalian cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Pro17 & Gly24 |
Form : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Bio-activity : | Measured by its binding ability in a functional ELISA. When Recombinant Human LILRA1/CD85i/LIR-6 is coated at 2 µg/mL, Recombinant Human Angiopoietin-like 7/ANGPTL7 binds with an ED50 = 0.3-1.8 µg/mL. |
Molecular Mass : | Predicted Molecular Mass: 49 kDa SDS-PAGE: 62-76 kDa, reducing conditions |
Endotoxin : | <0.1 EU per 1 μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 250 μg/mL in PBS. |
Gene Name : | LILRA1 leukocyte immunoglobulin like receptor A1 [ Homo sapiens ] |
Official Symbol : | LILRA1 |
Synonyms : | LIR6; CD85I; LIR-6; CD85 antigen-like family member I; leucocyte Ig-like receptor A1; leukocyte immunoglobulin-like receptor 6; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 |
Gene ID : | 11024 |
mRNA Refseq : | NM_001278318 |
Protein Refseq : | NP_001265247 |
MIM : | 604810 |
UniProt ID : | O75019 |
Products Types
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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