Recombinant Human LILRB1 protein, Fc-tagged
Cat.No. : | LILRB1-110H |
Product Overview : | Recombinant Human LILRB1 protein (Gly24-His458), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | CD85 antigen-like family member J (CD85J) is also known as Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1 or LIR-1), Immunoglobulin-like transcript 2 (ILT-2), Monocyte/macrophage immunoglobulin-like receptor 7 (MIR7), which belongs to leukocyte immunoglobulin-like receptor (LIR) family. CD85J/LILRB1 Contains 4 Ig-like C2-type (immunoglobulin-like) domains. CD85J/ LIR-1 is expressed predominantly on B-cells and monocytes. CD85J is receptor for class I MHC antigens and recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles and is also receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. CD85J/LILRB1 interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. CD85J/LILRB1 inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calciumions. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Form : | Lyophilized from 0.22 um filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 73.8 kDa. The protein migrates as 90-105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 435 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >92% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | LILRB1 |
Official Symbol : | LILRB1 |
Synonyms : | LILRB1; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; leukocyte immunoglobulin-like receptor subfamily B member 1; CD85; CD85j; ILT2; LIR 1; LIR1; MIR 7; ILT-2; CD85 antigen; Ig-like transcript 2; leukocyte Ig-like receptor-1; immunoglobulin-like transcript 2; CD85 antigen-like family member J; leukocyte immunoglobulin-like receptor 1; monocyte/macrophage immunoglobulin-like receptor 7; leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform; MIR7; CD85J; LIR-1; MIR-7; FLJ37515 |
Gene ID : | 10859 |
mRNA Refseq : | NM_001081637 |
Protein Refseq : | NP_001075106 |
MIM : | 604811 |
UniProt ID : | Q8NHL6 |
Products Types
◆ Recombinant Protein | ||
LILRB1-353H | Recombinant Human LILRB1 Protein, Fc-tagged | +Inquiry |
LILRB1-028H | Active Recombinant Human LILRB1 Protein, His-tagged | +Inquiry |
LILRB1-646H | Recombinant Human LILRB1 Protein, MYC/DDK-tagged | +Inquiry |
LILRB1-0333C | Recombinant Cynomolgus LILRB1 protein, His-tagged | +Inquiry |
LILRB1-01R | Recombinant Rhesus Macaque LILRB1 protein, His-tagged | +Inquiry |
◆ Lysates | ||
LILRB1-774HCL | Recombinant Human LILRB1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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