| Description : |
Lysyl oxidase homolog 2 is a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. LOXL2 can also crosslink collagen type IV and hence influence the sprouting of new blood vessels. LOXL2 is an enzyme that is up-regulated in several types of cancer and is associated with a poorer prognosis. LOXL2 changes the structure of histones and thus changes the shape of the cells, making it easier for the cancer cells to metastasize. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Avi/His |
| Form : |
Supplied as a 0.2 μm filtered solution of 50mM Sodium borate, 10mM CaCl,1.2M Urea, pH8.0. |
| Protein length : |
Gln26-Gln774 |
| AA Sequence : |
QYDSWPHYPEYFQQPAPEYHQPQAP ANVAKIQLRLAGQKRKHSEGRVEVY YDGQWGTVCDDDFSI HAAHVVCRELGYVEAKSWTASSSYG KGEGPIWLDNLHCTGNEATLAACTS NGWGVTDCKHTEDVG VVCSDKRIPGFKFDNSLINQIENLN IQVEDIRIRAILSTYRKRTPVMEGY VEVKEGKTWKQICDK HWTAKNSRVVCGMFGFPGERTYNTK VYKMFASRRKQRYWPFSMDCTGTEA HISSCKLGPQVSLDP MKNVTCENGLPAVVSCVPGQVFSPD GPSRFRKAYKPEQPLVRLRGGAYIG EGRVEVLKNGEWGTV CDDKWDLVSASVVCRELGFGSAKEA VTGSRLGQGIGPIHLNEIQCTGNEK SIIDCKFNAESQGCN HEEDAGVRCNTPAMGLQKKLRLNGG RNPYEGRVEVLVERNGSLVWGMVCG QNWGIVEAMVVCRQL GLGFASNAFQETWYWHGDVNSNKVV MSGVKCSGTELSLAHCRHDGEDVAC PQGGVQYGAGVACSE TAPDLVLNAEMVQQTTYLEDRPMFM LQCAMEENCLSASAAQTDPTTGYRR LLRFSSQIHNNGQSD FRPKNGRHAWIWHDCHRHYHSMEVF THYDLLNLNGTKVAEGHKASFCLED TECEGDIQKNYECAN FGDQGITMGCWDMYRHDIDCQWVDI TDVPPGDYLFQVVINPNFEVAESDY SNNIMKCRSRYDGHR IWMYNCHIGGSFSEETEKKFEHFSG LLNNQLSPQGLNDIFEAQKIEWHEH HHHHH |
| Endotoxin : |
Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test. |
| Purity : |
Greater than 95% as determined by reducing SDS-PAGE. |
| Storage : |
Store at < -20 centigrade, stable for 6 months after receipt.
Please minimize freeze-thaw cycles. |
| Shipping : |
The product is shipped on dry ice/ice packs. |
