Recombinant Human LRP6 protein, His-tagged
Cat.No. : | LRP6-7875H |
Product Overview : | Recombinant Human LRP6 aa. (Trp981~Gly1213) fused with N-terminal His tag was produced in E. coli cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | 30kDa as determined by SDS-PAGE reducing conditions. |
Protein length : | Trp981~Gly1213 |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | >92% |
Characteristic : | The isoelectric point is 6.3. |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB |
Stability : | The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Concentration : | 200μg/mL |
Storage Buffer : | 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300. |
Reconstitution : | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Gene Name : | LRP6 LDL receptor related protein 6 [ Homo sapiens (human) ] |
Official Symbol : | LRP6 |
Synonyms : | LRP6; LDL receptor related protein 6; ADCAD2; STHAG7; low-density lipoprotein receptor-related protein 6; LRP-6 |
Gene ID : | 4040 |
mRNA Refseq : | NM_002336.2 |
Protein Refseq : | NP_002327.2 |
UniProt ID : | O75581 |
Products Types
◆ Recombinant Protein | ||
LRP6-7875HB | Recombinant Human LRP6 Protein, N-His tagged, Avi-biotinylated | +Inquiry |
Lrp6-1338M | Recombinant Mouse Lrp6 Protein, MYC/DDK-tagged | +Inquiry |
LRP6-122H | Recombinant Human LRP6 Protein, His (Fc)-Avi-tagged | +Inquiry |
LRP6-2372R | Recombinant Rhesus Macaque LRP6 Protein, His (Fc)-Avi-tagged | +Inquiry |
Lrp6-5166M | Recombinant Mouse Lrp6 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
LRP6-4654HCL | Recombinant Human LRP6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionLRP6 interacts with Wnt signaling pathways by forming a complex with Frizzled receptors, initiating Wnt pathway activation.
LRP6 is predominantly localized on the cell membrane, where it acts as a co-receptor for Wnt ligands.
Specific Wnt ligands or co-receptors that LRP6 interacts with include Wnt-1 and Wnt-3a, influencing Wnt pathway activation.
Dysregulation or abnormal expression of LRP6 is associated with conditions such as cancer and osteoporosis.
LRP6 contributes to the regulation of cell proliferation, differentiation, and tissue development by modulating Wnt signaling.
There are potential therapeutic implications related to LRP6 in diseases involving Wnt signaling, making it a target for drug development.
Low-density lipoprotein receptor-related protein 6 (LRP6) functions in cellular processes, primarily playing a role in Wnt signaling.
Customer Reviews (3)
Write a reviewWe appreciated the product's role in supporting open-access initiatives, promoting accessibility to scientific knowledge.
We appreciated the product's recognition in peer-reviewed journals, further establishing its importance in our field.
The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.
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