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Recombinant Human LRP6 protein, His-tagged

Cat.No. : LRP6-7875H
Product Overview : Recombinant Human LRP6 aa. (Trp981~Gly1213) fused with N-terminal His tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Source : E. coli
Species : Human
Tag : His
Form : Freeze-dried powder
Molecular Mass : 30kDa as determined by SDS-PAGE reducing conditions.
Protein length : Trp981~Gly1213
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >92%
Characteristic : The isoelectric point is 6.3.
Applications : Positive Control; Immunogen; SDS-PAGE; WB
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Concentration : 200μg/mL
Storage Buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : LRP6 LDL receptor related protein 6 [ Homo sapiens (human) ]
Official Symbol : LRP6
Synonyms : LRP6; LDL receptor related protein 6; ADCAD2; STHAG7; low-density lipoprotein receptor-related protein 6; LRP-6
Gene ID : 4040
mRNA Refseq : NM_002336.2
Protein Refseq : NP_002327.2
UniProt ID : O75581

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does LRP6 interact with Wnt signaling pathways, and what is its role in modulating Wnt signaling? 02/13/2022

LRP6 interacts with Wnt signaling pathways by forming a complex with Frizzled receptors, initiating Wnt pathway activation.

In which cellular compartments is LRP6 predominantly localized? 01/12/2021

LRP6 is predominantly localized on the cell membrane, where it acts as a co-receptor for Wnt ligands.

Are there specific Wnt ligands or co-receptors that LRP6 interacts with, influencing Wnt pathway activation? 11/18/2019

Specific Wnt ligands or co-receptors that LRP6 interacts with include Wnt-1 and Wnt-3a, influencing Wnt pathway activation.

What diseases or conditions are associated with dysregulation or abnormal expression of LRP6? 04/25/2018

Dysregulation or abnormal expression of LRP6 is associated with conditions such as cancer and osteoporosis.

How does LRP6 contribute to the regulation of cell proliferation, differentiation, or tissue development? 05/28/2017

LRP6 contributes to the regulation of cell proliferation, differentiation, and tissue development by modulating Wnt signaling.

Are there therapeutic implications or potential targets related to LRP6 in diseases involving Wnt signaling? 08/19/2016

There are potential therapeutic implications related to LRP6 in diseases involving Wnt signaling, making it a target for drug development.

What is the primary function of Low-density lipoprotein receptor-related protein 6 (LRP6) in cellular processes and signaling? 03/31/2016

Low-density lipoprotein receptor-related protein 6 (LRP6) functions in cellular processes, primarily playing a role in Wnt signaling.

Customer Reviews (3)

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Reviews
04/07/2021

    We appreciated the product's role in supporting open-access initiatives, promoting accessibility to scientific knowledge.

    09/11/2020

      We appreciated the product's recognition in peer-reviewed journals, further establishing its importance in our field.

      01/17/2018

        The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.

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