Recombinant Human MALT1 protein, His/Thioredoxin-tagged

• Cat.No.: MALT1-857H
• Product Overview: Recombinant Human MALT1((Gln 2-Ile57) fused with His/Thioredoxin tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Source: E. coli
• Species: Human
• Tag: His/Thioredoxin
• Form: Supplied as a 0.45 µm filtered solution in 50 mM NaH2PO4 (pH 7.4), 0.3 M NaCl, 80 mM imidazole, 6 M urea.
• Molecular Mass: 27 kDa (including N-terminal thioredoxin tag)
• Purity: ~0.9
• Applications: ELISA, EIA, protein-protein interaction studies, Western Blotting, Dot Blotting, Immunoprecipitation, Protein Array
• Storage: Upon arrival, the protein may be stored for 2 weeks at 4 centigrade. For long term storage, it is recommended to store at -20 centigrade or -80 centigrade in appropriate aliquots. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 [ Homo sapiens ]
• Official Symbol: MALT1
• Synonyms: MALT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; MLT; mucosa-associated lymphoid tissue lymphoma translocation protein 1; paracaspase; caspase-like protein; MALT associated translocation; MALT lymphoma-associated translocation; MALT-lymphoma associated translocation; MLT1; DKFZp434L132
• Gene ID: 10892
• mRNA Refseq: NM_006785
• Protein Refseq: NP_006776
• MIM: 604860
• UniProt ID: Q9UDY8
• Chromosome Location: 18q21
• Pathway: Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; BCR signaling pathway, organism-specific biosystem; Canonical NF-kappaB pathway, organism-specific biosystem; Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem
• Function: cysteine-type endopeptidase activity; contributes_to kinase activator activity; peptidase activity; protein binding; protein self-association; signal transducer activity; ubiquitin-protein ligase activity