Active Recombinant Human MANF Protein

• Cat.No.: MANF-702H
• Product Overview: Recombinant human MANF protein was expressed from CHO-based cell line and purified by QMCF Technology.

Specification

• Description: MANF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- induced degeneration of dopamine neurons in rodent models of Parkinson’s disease. When administered after 6-OHDA-lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta.
• Source: CHO
• Species: Human
• Form: PBS pH 7.4.
• Bio-activity: Protein is biologically active. Suitable for cell culture and in vivo testing. Human recombinant MANF has been tested in rat 6-OHDA model of Parkinson's disease and shown neureprotection and neurorestoration. MANF has also shown neuroprotection in animal models of stroke.
• Molecular Mass: Approximately 18.1 kDa, a single non-glycosylated polypeptide chain containing 158 amino acids.
• Endotoxin: Less than 1EU/mg of protein as determined by LAL method.
• Storage: Store at -70 centigrade upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: mesencephalic astrocyte derived neurotrophic factor
• Official Symbol: MANF
• Synonyms: Mesencephalic astrocyte-derived neurotrophic factor – MANF; ARMET; ARP
• Gene ID: 7873
• mRNA Refseq: NM_006010.4
• Protein Refseq: NP_006001.3
• MIM: 601916
• UniProt ID: P55145