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Recombinant Human MBL2 protein, His & GST-tagged

Cat.No. : MBL2-575H
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  • Gene Information
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Product overview : Recombinant Human MBL2 (P11226) aa. (Leu130~Ile248) fused with His & GST tag was produced in E. coli cells.
Description : This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases.
Source : E. coli
Species : Human
Tag : His & GST
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 43kDa; Accurate Molecular Mass: 43kDa as determined by SDS-PAGE reducing conditions.
Protein length : Leu130~Ile248
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >98%
Characteristic : Isoelectric point is 5.8.
Applications : Cell culture; Activity Assays; In vivo assays.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : 20mM Tris, 150mM NaCl,pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex
Gene Name : MBL2 mannose binding lectin 2 [ Homo sapiens (human) ]
Official Symbol : MBL2
Synonyms : MBL2; mannose binding lectin 2; MBL; MBP; MBP1; MBPD; MBL2D; MBP-C; COLEC1; HSMBPC; mannose-binding protein C; collectin-1; mannan-binding lectin; mannose-binding lectin (protein C) 2, soluble (opsonic defect); mannose-binding lectin 2, soluble (opsonic defect)
Gene ID : 4153
mRNA Refseq : NM_000242.2
Protein Refseq : NP_000233.1
UniProt ID : P11226

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does MBL2 contribute to the defense against infections? 12/21/2022

MBL2 binds to the surface of pathogens, triggering the activation of the complement system, which leads to the destruction of the pathogens.

Can MBL2 be used as a biomarker for certain medical conditions? 07/01/2022

Yes, altered levels of MBL2 in the blood can serve as a biomarker for certain infections and immune-related disorders.

Are there any diseases associated with MBL2 deficiencies? 05/20/2018

Yes, MBL2 deficiencies have been linked to an increased susceptibility to various infections and autoimmune diseases.

Are there any genetic variations in the MBL2 gene? 06/27/2017

Yes, genetic variations in the MBL2 gene can lead to variations in MBL2 protein levels and functionality.

Can MBL2 be a target for drug development? 12/03/2016

Yes, targeting MBL2 in drug development may offer new avenues for modulating the immune response and treating infectious and autoimmune diseases.

Customer Reviews (3)

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Reviews
09/05/2019

    The use of MBL2 protein in such analyses provides valuable structural insights that contribute to the elucidation of ANO2's functional mechanisms and potential drug targeting sites.

    01/28/2018

      MBL2 protein has shown great utility in protein electron microscopy structure analysis.

      06/06/2016

        By visualizing the structural features, interactions, and conformational changes of MBL2, researchers gain valuable insights into its function and potential for therapeutic interventions.

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