Recombinant Human MCM6 Protein, GST-tagged

• Cat.No.: MCM6-4519H
• Product Overview: Human MCM6 full-length ORF ( NP_005906.2, 1 a.a. - 821 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 119.3 kDa
• AA Sequence: MDLAAAAEPGAGSQHLEVRDEVAEK CQKLFLDFLEEFQSSDGEIKYLQLA EELIRPERNTLVVSFVDLEQFNQQL STTIQEEFYRVYPYLCRALKTFVKD RKEIPLAKDFYVAFQDLPTRHKIRE LTSSRIGLLTRISGQVVRTHPVHPE LVSGTFLCLDCQTVIRDVEQQFKYT QPNICRNPVCANRRRFLLDTNKSRF VDFQKVRIQETQAELPRGSIPRSLE VILRAEAVESAQAGDKCDFTGTLIV VPDVSKLSTPGARAETNSRVSGVDG YETEGIRGLRALGVRDLSYRLVFLA CCVAPTNPRFGGKELRDEEQTAESI KNQMTVKEWEKVFEMSQDKNLYHNL CTSLFPTIHGNDEVKRGVLLMLFGG VPKTTGEGTSLRGDINVCIVGDPST AKSQFLKHVEEFSPRAVYTSGKASS AAGLTAAVVRDEESHEFVIEAGALM LADNGVCCIDEFDKMDVRDQVAIHE AMEQQTISITKAGVKATLNARTSIL AAANPISGHYDRSKSLKQNINLSAP IMSRFDLFFILVDECNEVTDYAIAR RIVDLHSRIEESIDRVYSLDDIRRY LLFARQFKPKISKESEDFIVEQYKH LRQRDGSGVTKSSWRITVRQLESMI RLSEAMARMHCCDEVQPKHVKEAFR LLNKSIIRVETPDVNLDQEEEIQME VDEGAGGINGHADSPAPVNGINGYN EDINQESAPKASLRLGFSEYCRISN LIVLHLRKVEEEEDESALKRSELVN WYLKEIESEIDSEEELINKKRIIEK VIHRLTHYDHVLIELTQAGLKGSTE GSESYEEDPYLVVNPNYLLED
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MCM6 minichromosome maintenance complex component 6 [ Homo sapiens ]
• Official Symbol: MCM6
• Synonyms: MCM6; minichromosome maintenance complex component 6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) , minichromosome maintenance deficient (mis5, S. pombe) 6 , minichromosome maintenance deficient 6 homolog (S. cerevisiae); DNA replication licensing factor MCM6; Mis5; MIS5 homolog (S.pombe); MIS5 homolog; minichromosome maintenance deficient 6 homolog; minichromosome maintenance deficient (mis5, S. pombe) 6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe); P105MCM; MCG40308
• Gene ID: 4175
• mRNA Refseq: NM_005915
• Protein Refseq: NP_005906
• MIM: 601806
• UniProt ID: Q14566