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Active Recombinant Human MLL2 protein, GST-tagged

Cat.No. : MLL2-190H
Product Overview : Recombinant Human MLL2(5317-end) fused with GST tag at N-terminal was expressed in Insect cells.
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  • Gene Information
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Description : Histone-lysine N-methyltransferase 2D, also known as mixed-lineage leukemia 2 (MLL2), methylates 'Lys-4' of histone H3 (H3K4me). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. MLL2/KMT2D is among the most frequently mutated genes in a variety of pediatric tumors.
Source : Insect cells
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 2.5 nmol/min/mg
Molecular Mass : 51 kDa
Protein length : 5317-end
Purity : >80%
Applications : Methyltransferase Assay
Stability : 1 year at -70 centigrade from the date of shipment
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : MLL2 myeloid/lymphoid or mixed-lineage leukemia 2 [ Homo sapiens ]
Official Symbol : MLL2
Synonyms : MLL2; myeloid/lymphoid or mixed-lineage leukemia 2; TNRC21, trinucleotide repeat containing 21; histone-lysine N-methyltransferase MLL2; ALR; CAGL114; KMT2D; MLL4; ALL1-related protein; Kabuki make-up syndrome; lysine N-methyltransferase 2B; lysine N-meth
Gene ID : 8085
mRNA Refseq : NM_003482
Protein Refseq : NP_003473
MIM : 602113
UniProt ID : O14686
Chromosome Location : 12q13.12
Pathway : Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem;
Function : DNA binding; histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; protein binding; transcription regulatory region DNA binding; transferase activity; zinc ion binding;

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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