Active Recombinant Human MLL2 protein, GST-tagged
Cat.No. : | MLL2-190H |
Product Overview : | Recombinant Human MLL2(5317-end) fused with GST tag at N-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | Histone-lysine N-methyltransferase 2D, also known as mixed-lineage leukemia 2 (MLL2), methylates 'Lys-4' of histone H3 (H3K4me). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. MLL2/KMT2D is among the most frequently mutated genes in a variety of pediatric tumors. |
Source : | Insect cells |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 2.5 nmol/min/mg |
Molecular Mass : | 51 kDa |
Protein length : | 5317-end |
Purity : | >80% |
Applications : | Methyltransferase Assay |
Stability : | 1 year at -70 centigrade from the date of shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name : | MLL2 myeloid/lymphoid or mixed-lineage leukemia 2 [ Homo sapiens ] |
Official Symbol : | MLL2 |
Synonyms : | MLL2; myeloid/lymphoid or mixed-lineage leukemia 2; TNRC21, trinucleotide repeat containing 21; histone-lysine N-methyltransferase MLL2; ALR; CAGL114; KMT2D; MLL4; ALL1-related protein; Kabuki make-up syndrome; lysine N-methyltransferase 2B; lysine N-meth |
Gene ID : | 8085 |
mRNA Refseq : | NM_003482 |
Protein Refseq : | NP_003473 |
MIM : | 602113 |
UniProt ID : | O14686 |
Chromosome Location : | 12q13.12 |
Pathway : | Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; |
Function : | DNA binding; histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; protein binding; transcription regulatory region DNA binding; transferase activity; zinc ion binding; |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All MLL2 Products
Required fields are marked with *
My Review for All MLL2 Products
Required fields are marked with *
0
Inquiry Basket