Recombinant Human MLLT1 protein, GST-tagged

• Cat.No.: MLLT1-268H
• Product Overview: Recombinant Human MLLT1(1-150 aa)(YEATS DOMAIN, Y78A) fused with GST tag at N-terminal was expressed in E. coli.

Specification

• Description: The ENL protein is part of the super elongation complex regulating RNA Pol II transcription. A chromosomal translocation resulting in an MLL-ENL fusion is involved in pediatric Acute Lymphoblastic Leukemia. ENL YEATS Domain, Y78A, Recombinant Human contains a substitution of alanine for tyrosine at position 78.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Recombinant GST-tagged protein at 1 mg/ml in 50 mM HEPES pH 7.3, 200 mM NaCl, 1 mM DTT, 10% glycerol.
• Molecular Mass: 42 kDa
• Applications: ENL YEATS Domain, Y78A, Recombinant Human is useful for protein binding and screening experiments examining acetylated protein substrates.
• Storage: Stable for six months at -80 centigrade from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 [ Homo sapiens ]
• Official Symbol: MLLT1
• Synonyms: MLLT1; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1; myeloid/lymphoid or mixed lineage leukemia (trithorax (Drosophila) homolog); translocated to, 1; protein ENL; ENL; LTG19; YEATS1; ENL/MLL fusion; MLLT1/MLL fusion; YEATS domain-containing protein 1; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1
• Gene ID: 4298
• mRNA Refseq: NM_005934
• Protein Refseq: NP_005925
• MIM: 159556
• UniProt ID: Q03111
• Chromosome Location: 19p13.3
• Pathway: Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem