Active Recombinant Human MMP13 protein
Cat.No. : | MMP13-27H |
Product Overview : | Recombinant Human MMP13 was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. |
Source : | E. coli |
Species : | Human |
Form : | The protein Solution (100 µg/ml) in 0.05M Tris-HCl buffer, pH 7.6, containing 0.2M NaCl, 5mM CaCl2, 20µM ZnSO4 and 0.1% BSA and NaN3. |
Bio-activity : | The specific biological activity measured by the ability of fibrin lysis in agarose plate was found to be 80000U/mg. |
Molecular Mass : | 27 kDa |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Storage : | MMP-13 although stable at 4 centigrade for 1 week, should be stored desiccated below -18 centigrade. Please prevent freeze-thaw cycles. |
Gene Name : | MMP13 matrix metallopeptidase 13 (collagenase 3) [ Homo sapiens ] |
Official Symbol : | MMP13 |
Synonyms : | MMP13; matrix metallopeptidase 13 (collagenase 3); matrix metalloproteinase 13 (collagenase 3); collagenase 3; CLG3; MMP-13; MANDP1; |
Gene ID : | 4322 |
mRNA Refseq : | NM_002427 |
Protein Refseq : | NP_002418 |
MIM : | 600108 |
UniProt ID : | P45452 |
Chromosome Location : | 11q22.3 |
Pathway : | Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem; |
Function : | calcium ion binding; calcium-dependent protein binding; fibronectin binding; low-density lipoprotein particle receptor binding; metalloendopeptidase activity; peptidase activity; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
MMP13-01H | Active Recombinant Human MMP13 (F175D) Protein | +Inquiry |
MMP13-0833H | Recombinant Human MMP13 Protein (E103-N274), His tagged | +Inquiry |
MMP13-1119C | Recombinant Cattle MMP13 Protein, His-tagged | +Inquiry |
MMP13-2045D | Recombinant Dog MMP13 Protein (28-478 aa), His-SUMO-tagged | +Inquiry |
MMP13-42H | Recombinant Human MMP-13 | +Inquiry |
◆ Lysates | ||
MMP13-4280HCL | Recombinant Human MMP13 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, targeting MMP13 has been explored as a potential therapeutic strategy to inhibit cancer metastasis and invasion.
Yes, MMP13 has been implicated in cardiovascular diseases by contributing to the remodeling of blood vessels and cardiac tissues.
MMP13 facilitates tumor invasion and metastasis by breaking down the extracellular matrix and promoting the migration of cancer cells.
Certain genetic variations in the MMP13 gene have been linked to increased susceptibility to diseases such as osteoarthritis and cancer.
Some clinical trials are investigating drugs that specifically target MMP13 in various cancer types to assess their efficacy and safety.
Customer Reviews (3)
Write a reviewIts reliability and versatility make it an essential tool for investigating MMP13 protein's expression, function, and structural characteristics.
The use of MMP13 protein in this technique allows researchers to explore the intricate three-dimensional structure of the protein at a molecular level.
MMP13 protein is highly recommended for researchers due to its excellent performance in WB experiments and its utility in protein electron microscopy structure analysis.
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