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Active Recombinant Human MUC16 Protein, His-tagged

Cat.No. : MUC16-42H
Product Overview : Recombinant Human CA125/MUC16 protein Met13360-Gln14347 (Met13472Thr & Gln13957Lys) protein with a C-terminal 6-His tag expressed in CHO.
  • Specification
  • Gene Information
  • Related Products
Source : CHO
Species : Human
Tag : His
Predicted N Terminal : Met13360
Form : Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity : Measured by its binding ability in a functional ELISA. When Recombinant Human CA125/MUC16 is coated at 1 μg/mL (100 μL/well), the concentration of Recombinant Human Galectin‑3 that produces 50% of the optimal binding response is found to be approximately 0.35-1.4 μg/mL.
Molecular Mass : 110 kDa
Endotoxin : <0.10 EU per 1 μg of the protein by the LAL method.
Purity : >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage : Avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 250 μg/mL in PBS.
Gene Name : MUC16
Official Symbol : MUC16 mucin 16, cell surface associated [ Homo sapiens (human) ]
Synonyms : MUC16; mucin 16, cell surface associated; CA125; mucin-16; CA125 ovarian cancer antigen; ovarian cancer-related tumor marker CA125; ovarian carcinoma antigen CA125; CA-125; CA125MUC-16; FLJ14303; MUC16; mucin 16, cell surface associated; mucin-16; Ovarian cancer-related tumor marker CA125; Ovarian carcinoma antigen CA125
Gene ID : 94025
mRNA Refseq : NM_024690
Protein Refseq : NP_078966
MIM : 606154
UniProt ID : Q8WXI7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does MUC16 interact with other components of the epithelial barrier and immune system? 10/15/2022

MUC16 works with other mucins and immune components to maintain epithelial barrier function and immune responses.

How does MUC16 contribute to the formation of the mucosal barrier? 10/12/2022

It aids in forming the mucosal barrier, protecting against pathogens and mechanical damage.

What potential therapeutic applications arise from targeting MUC16 in cancer treatment? 08/02/2021

Targeting MUC16 in cancer therapy, especially in ovarian cancer, could be effective in inhibiting tumor growth and spread.

What is the impact of altered MUC16 activity on inflammatory and infectious diseases? 03/15/2021

Altered MUC16 activity can impact the body's defense against inflammation and infection.

What is the primary role of MUC16 in epithelial cell function? 05/03/2020

MUC16, a mucin protein, is essential for maintaining the protective mucous layer on epithelial surfaces.

What role does MUC16 play in cancer, particularly ovarian cancer? 02/15/2018

MUC16 is associated with cancer progression, particularly in ovarian cancer, where it may facilitate tumor growth and metastasis.

How do genetic variations in MUC16 affect its function in mucosal protection and cancer development? 04/03/2017

Genetic variations in MUC16 can lead to differences in mucosal integrity and potentially influence cancer susceptibility.

Customer Reviews (3)

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Reviews
07/28/2020

    Critical for decision-making. Supports our research endeavors.

    05/24/2018

      Expert service quality. Valuable for research integrity.

      06/05/2017

        Dependable partner in experiments. Consistent and trustworthy.

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