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Recombinant Human MUC16 (Q72L) Protein, His-tagged

Cat.No. : MUC16-704H
Product Overview : Recombinant Human MUC16 protein (NM_012250,Q72L) was expressed in E. coli with His tag.
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Description : Ras proteins are members of the superfamily of small GTP-binding proteins that function as molecular switches controlling a variety of signaling and transport pathways. The Ras family of GTP-binding proteins consists of the classical Ras (Ha-, K-, and N-), R-Ras, Rap1, Rap2, Ral, Rheb, Rin, Rit, TC21/R-Ras2, and M-Ras/R-Ras3 (M-Ras). TC21 is a Ras-like GTPase with high oncogenic potential that is found mutated in some human tumors and overexpressed in breast cancer cell lines. It binds physically to c-Raf-1 in a GTP-dependent manner. TC21 (Q72L) is a constitutive active mutant of TC21.
Source : E. coli
Species : Human
Tag : His
Form : 25 mM HEPES pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 μM GDP and 50% glycerol
Purity : > 95 % (SDS-PAGE)
Storage : Store at -20 centigrade.
Gene Name : MUC16 mucin 16, cell surface associated [ Homo sapiens ]
Official Symbol : MUC16
Synonyms : CA125
Gene ID : 94025
mRNA Refseq : NM_024690.2
Protein Refseq : NP_078966.2
MIM : 606154
UniProt ID : Q8WXI7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does MUC16 interact with other components of the epithelial barrier and immune system? 10/15/2022

MUC16 works with other mucins and immune components to maintain epithelial barrier function and immune responses.

How does MUC16 contribute to the formation of the mucosal barrier? 10/12/2022

It aids in forming the mucosal barrier, protecting against pathogens and mechanical damage.

What potential therapeutic applications arise from targeting MUC16 in cancer treatment? 08/02/2021

Targeting MUC16 in cancer therapy, especially in ovarian cancer, could be effective in inhibiting tumor growth and spread.

What is the impact of altered MUC16 activity on inflammatory and infectious diseases? 03/15/2021

Altered MUC16 activity can impact the body's defense against inflammation and infection.

What is the primary role of MUC16 in epithelial cell function? 05/03/2020

MUC16, a mucin protein, is essential for maintaining the protective mucous layer on epithelial surfaces.

What role does MUC16 play in cancer, particularly ovarian cancer? 02/15/2018

MUC16 is associated with cancer progression, particularly in ovarian cancer, where it may facilitate tumor growth and metastasis.

How do genetic variations in MUC16 affect its function in mucosal protection and cancer development? 04/03/2017

Genetic variations in MUC16 can lead to differences in mucosal integrity and potentially influence cancer susceptibility.

Customer Reviews (3)

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Reviews
07/28/2020

    Critical for decision-making. Supports our research endeavors.

    05/24/2018

      Expert service quality. Valuable for research integrity.

      06/05/2017

        Dependable partner in experiments. Consistent and trustworthy.

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