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Recombinant Human MYC protein, His & GST-tagged

Cat.No. : MYC-574H
  • Specification
  • Gene Information
  • Related Products
Product overview : Recombinant Human MYC (P01106) aa. (Ser184~Ala454) fused with His & GST tag was produced in E. coli cells.
Description : The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
Source : E. coli
Species : Human
Tag : His & GST
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 60.2kDa; Accurate Molecular Mass: 65kDa as determined by SDS-PAGE reducing conditions.
Protein length : Ser184~Ala454
Purity : >98%
Characteristic : Isoelectric point is 6.6.
Applications : Cell culture; Activity Assays; In vivo assays.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : 20mM Tris, 150mM NaCl,pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex
Gene Name : MYC MYC proto-oncogene, bHLH transcription factor [ Homo sapiens (human) ]
Official Symbol : MYC
Synonyms : MYC; MYC proto-oncogene, bHLH transcription factor; MRTL; MYCC; c-Myc; bHLHe39; myc proto-oncogene protein; avian myelocytomatosis viral oncogene homolog; class E basic helix-loop-helix protein 39; myc-related translation/localization regulatory factor; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog
Gene ID : 4609
mRNA Refseq : NM_002467.4
Protein Refseq : NP_002458.2
UniProt ID : P01106

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How does overexpression of the MYC gene affect cardiovascular disease? 11/14/2022

Abnormal expression of MYC gene may affect the occurrence and progression of cardiovascular diseases such as atherosclerosis by regulating the proliferation of vascular smooth muscle cells and increasing the expression of endothelial cell-specific shear-related proteins.

Is the MYC gene a potential target for pancreatic cancer or drug therapy? 06/18/2022

Because of its important promotion role in pancreatic cancer, MYC gene is regarded as one of the potential targets and drug treatment directions for pancreatic cancer treatment, but specific research and related drugs need to be further verified.

How does the MYC gene regulate somatic cell proliferation through cell cycle progression? 05/13/2021

The MYC gene may affect the proliferation of somatic cells by regulating cell cycle progression, such as increasing the S-phase entry of the cell cycle and promoting the G1/S phase transition.

What is the role of the MYC gene in stomach cancer? 03/20/2021

Overexpression and defect of MYC in gastric cancer are associated with the occurrence, progression and prognosis of gastric cancer. MYC translocation and high expression predict a poor prognosis.

Is the MYC gene associated with hematopoietic stem cells? 07/10/2020

MYC gene may be involved in the proliferation and differentiation of hematopoietic stem cells, but the specific mechanism and role still need to be further elucidated.

How does abnormal expression of the MYC gene affect tumor progression? 10/30/2019

Abnormal expression of MYC gene may affect tumor progression and prognosis by activating cell cycle constants, apoptosis inhibition, and enhanced cell mobility.

Customer Reviews (3)

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Reviews
05/19/2022

    The reproducibility of MYC is very good, and the results remain consistent even after repeated experiments several times, which gives me more confidence in the experimental results.

    01/18/2020

      Stability of this protein was still very good when different chemicals or drugs were added, indicating its excellent anti-interference ability and stability.

      10/06/2019

        Due to stability of MYC in Western blot was very good and even prolonged storage did not affect its performance.

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