Recombinant Human MYC protein, His & GST-tagged
Cat.No. : | MYC-574H |
- Specification
- Gene Information
- Related Products
Product overview : | Recombinant Human MYC (P01106) aa. (Ser184~Ala454) fused with His & GST tag was produced in E. coli cells. |
Description : | The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. |
Source : | E. coli |
Species : | Human |
Tag : | His & GST |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 60.2kDa; Accurate Molecular Mass: 65kDa as determined by SDS-PAGE reducing conditions. |
Protein length : | Ser184~Ala454 |
Purity : | >98% |
Characteristic : | Isoelectric point is 6.6. |
Applications : | Cell culture; Activity Assays; In vivo assays. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | 20mM Tris, 150mM NaCl,pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% Trehalose and Proclin300. |
Reconstitution : | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex |
Gene Name : | MYC MYC proto-oncogene, bHLH transcription factor [ Homo sapiens (human) ] |
Official Symbol : | MYC |
Synonyms : | MYC; MYC proto-oncogene, bHLH transcription factor; MRTL; MYCC; c-Myc; bHLHe39; myc proto-oncogene protein; avian myelocytomatosis viral oncogene homolog; class E basic helix-loop-helix protein 39; myc-related translation/localization regulatory factor; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog |
Gene ID : | 4609 |
mRNA Refseq : | NM_002467.4 |
Protein Refseq : | NP_002458.2 |
UniProt ID : | P01106 |
Products Types
◆ Recombinant Protein | ||
MYC-5787H | Recombinant Human MYC Protein, GST-tagged | +Inquiry |
Myc-4239M | Recombinant Mouse Myc Protein, Myc/DDK-tagged | +Inquiry |
MYC-32H | Recombinant Active Human c-Myc Protein (1-454) | +Inquiry |
MYC-060H | Recombinant Human MYC Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
MYC-3498R | Recombinant Rat MYC Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
MYC-4039HCL | Recombinant Human MYC 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1785 | Myc Reporter Kit (Myc Signaling Pathway) | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionAbnormal expression of MYC gene may affect the occurrence and progression of cardiovascular diseases such as atherosclerosis by regulating the proliferation of vascular smooth muscle cells and increasing the expression of endothelial cell-specific shear-related proteins.
Because of its important promotion role in pancreatic cancer, MYC gene is regarded as one of the potential targets and drug treatment directions for pancreatic cancer treatment, but specific research and related drugs need to be further verified.
The MYC gene may affect the proliferation of somatic cells by regulating cell cycle progression, such as increasing the S-phase entry of the cell cycle and promoting the G1/S phase transition.
Overexpression and defect of MYC in gastric cancer are associated with the occurrence, progression and prognosis of gastric cancer. MYC translocation and high expression predict a poor prognosis.
MYC gene may be involved in the proliferation and differentiation of hematopoietic stem cells, but the specific mechanism and role still need to be further elucidated.
Abnormal expression of MYC gene may affect tumor progression and prognosis by activating cell cycle constants, apoptosis inhibition, and enhanced cell mobility.
Customer Reviews (3)
Write a reviewThe reproducibility of MYC is very good, and the results remain consistent even after repeated experiments several times, which gives me more confidence in the experimental results.
Stability of this protein was still very good when different chemicals or drugs were added, indicating its excellent anti-interference ability and stability.
Due to stability of MYC in Western blot was very good and even prolonged storage did not affect its performance.
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