Recombinant Human NOG protein, Fc-tagged
Cat.No. : | NOG-046H |
Product Overview : | Recombinant Human NOG (Gln28-Cys232) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
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Description : | Noggin is also known as NOG,SYM1, SYNS1 and is a secreted homodimeric glycoprotein whose scaffold contains a cystine-knot topology similar to that of BMPs.Secreted Noggin probably remains close to the cell surface due to its binding of heparincontaining proteoglycans.Noggin inhibits TGF-β signal transduction by binding to TGF-β family ligands and preventing them from binding to their corresponding receptors. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion. During embryogenesis, Noggin antagonizes specific BMPs at defined times, for example, during neural tube, somite and cardiomyocyte growth and patterning. During skeletal development, Noggin prevents chondrocyte hyperplasia, thus allowing proper formation of joints. During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions, addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state, or alternatively, to differentiate into dopaminergic neurons Noggin also appears to maintain adult stem cell populations in vivo, for example, maintaining neural stem cells within the hippocampus. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Predicted N Terminal : | Gln28 |
Form : | Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 49.8 kDa. The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Gln28-Cys232 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | NOG |
Official Symbol : | NOG |
Synonyms : | NOG; noggin; SYM1, symphalangism 1 (proximal) , synostoses (multiple) syndrome 1 , SYNS1; symphalangism 1 (proximal); SYM1; SYNS1 |
Gene ID : | 9241 |
mRNA Refseq : | NM_005450 |
Protein Refseq : | NP_005441 |
MIM : | 602991 |
UniProt ID : | Q13253 |
Products Types
◆ Recombinant Protein | ||
NOG-401H | Recombinant Human NOG Protein, Fc-tagged | +Inquiry |
Nog-4452M | Active Recombinant Mouse Nog Protein | +Inquiry |
NOG-321H | Recombinant Human NOG Protein, His-tagged | +Inquiry |
Nog-10603M | Recombinant Mouse Nog Protein, His (Fc)-Avi-tagged | +Inquiry |
Nog-28M | Recombinant Mouse/Rat Nog Protein | +Inquiry |
◆ Lysates | ||
NOG-2414HCL | Recombinant Human NOG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionNOG inhibits BMP signaling, critical for tissue development and repair processes.
NOG modulates embryonic patterning and organogenesis, guiding proper organ development.
Changes in NOG expression or function can lead to congenital anomalies due to disrupted developmental processes.
NOG regulates stem cell differentiation, influencing their development into various tissue types.
NOG plays a key role in skeletal development by regulating bone growth and differentiation.
NOG influences neural development, impacting the formation and specialization of neural cells.
NOG is important for joint and cartilage health, potentially impacting arthritis progression.
Customer Reviews (3)
Write a reviewEfficient peptide synthesis, accelerates our peptide research projects.
Fast and reliable protein expression, aids our experiments significantly.
Dependable antibody validation, crucial for our immunoprecipitation studies.
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