Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human OTX2 Protein, His-tagged

Cat.No. : OTX2-26H
Product Overview : Recombinant protein of human orthodenticle homeobox 2 (OTX2), transcript variant 1, full length, fused to HIS tag at N-terminal , expressed in E.Coli
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012].
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 31.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Concentration : >50 µg/mL as determined by microplate BCA method
Storage Buffer : 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.
Gene Name : OTX2 orthodenticle homeobox 2 [ Homo sapiens (human) ]
Official Symbol : OTX2
Synonyms : OTX2; orthodenticle homeobox 2; CPHD6; MCOPS5; homeobox protein OTX2; orthodenticle homolog 2
Gene ID : 5015
mRNA Refseq : NM_001270523
Protein Refseq : NP_001257452
MIM : 600037
UniProt ID : P32243

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any specific drugs targeting OTX2 currently in development? 09/15/2022

As of my last knowledge update, there were no specific drugs targeting OTX2 in advanced stages of development, but ongoing research might uncover potential drug candidates.

Can OTX2 be a target for gene therapy? 09/29/2020

Yes, gene therapy targeting the OTX2 gene is being investigated as a potential approach for treating disorders related to OTX2 dysfunction.

Can alterations in OTX2 expression be detected through diagnostic tests? 05/13/2017

While not yet widely used in clinical practice, diagnostic tests assessing OTX2 expression levels may become relevant in the future for certain developmental and neurological disorders.

How is OTX2 relevant to cancer research? 12/26/2016

OTX2 has been implicated in certain types of brain tumors, and understanding its role in cancer may provide insights into potential targeted therapies.

Are there any ongoing clinical trials involving OTX2? 12/20/2016

As of my last knowledge update in January 2022, specific clinical trials involving OTX2 were not widely reported. However, ongoing research may have progressed since then.

Customer Reviews (3)

Write a review
Reviews
02/18/2023

    The OTX2 protein is of exceptional quality, meeting all my experimental requirements with precision and reliability.

    06/05/2020

      This dedication ensures that I have access to the most advanced and reliable protein in my studies, enhancing the overall quality and impact of my research outcomes.

      06/11/2018

        This exceptional level of support enables me to overcome challenges efficiently and progress smoothly with my research.

        Ask a Question for All OTX2 Products

        Required fields are marked with *

        My Review for All OTX2 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends