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Recombinant Human PADI4 Protein, His-tagged

Cat.No. : PADI4-293H
Product Overview : Recombinant human PADI4 (Met1-Pro663) was expressed with a polyhistidine tag at the N-terminus.
  • Specification
  • Gene Information
  • Related Products
Source : Baculovirus-Insect Cells
Species : Human
Tag : His
Predicted N Terminal : Met
Form : Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4, 5%~8% trehalose and mannitol.
Molecular Mass : The recombinant human PADI4 consists 663 amino acids and predicts a molecular mass of 74 kDa.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >95 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage : Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : PADI4 peptidyl arginine deiminase, type IV [ Homo sapiens ]
Official Symbol : PADI4
Synonyms : PADI4; peptidyl arginine deiminase, type IV; PADI5, peptidyl arginine deiminase, type V; protein-arginine deiminase type-4; PAD; PDI4; PDI5; HL-60 PAD; PADI-H protein; protein-arginine deiminase type IV; peptidyl arginine deiminase, type V; PAD4; PADI5;
Gene ID : 23569
mRNA Refseq : NM_012387
Protein Refseq : NP_036519
MIM : 605347
UniProt ID : Q9UM07
Chromosome Location : 1p36.13
Pathway : protein citrullination, organism-specific biosystem; protein citrullination, conserved biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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In which tissues or cell types is PADI4 predominantly expressed? 09/25/2022

PADI4 is predominantly expressed in various tissues, including synovial tissues, immune cells, and certain epithelial cells.

How does PADI4 contribute to the post-translational modification of proteins, particularly through citrullination? 07/27/2020

PADI4 plays a crucial role in citrullination, a process that converts arginine residues to citrulline, influencing protein structure and function.

What is the primary function of peptidyl arginine deiminase 4 (PADI4) in cellular processes? 06/16/2020

Peptidyl arginine deiminase 4 (PADI4) primarily functions in cellular processes, contributing to the post-translational modification of proteins through citrullination.

What is the role of PADI4 in the regulation of immune responses and autoimmune diseases? 05/25/2020

In the regulation of immune responses, PADI4 is implicated in autoimmune diseases such as rheumatoid arthritis, where it contributes to autoantibody generation.

How is dysregulation or abnormal expression of PADI4 implicated in various diseases, including rheumatoid arthritis? 12/31/2019

Dysregulation or abnormal expression of PADI4 is associated with autoimmune disorders, particularly rheumatoid arthritis.

Are there therapeutic implications or potential targets related to PADI4 in the context of autoimmune disorders? 08/26/2018

There are potential therapeutic implications related to targeting PADI4 in autoimmune disorders, making it a focus for drug development.

Are there specific substrates of PADI4, and what cellular processes are affected by its citrullination activity? 07/14/2016

Specific substrates of PADI4 include histones and other proteins, impacting cellular processes like gene regulation and signaling pathways.

Customer Reviews (3)

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Reviews
12/05/2020

    The minimal variation across different batches enhanced the repeatability of our results.

    06/14/2018

      The product's role in promoting collaboration and teamwork positively impacted the quality of our research.

      01/23/2017

        The product's compatibility with various instruments and techniques promoted teamwork in our interdisciplinary projects.

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