Recombinant Human PRLR protein, GST-tagged
Cat.No. : | PRLR-59H |
Product Overview : | Recombinant Human PRLR(1 a.a. - 622 a.a.) fused with GST tag at N-terminal was expressed in NS0. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Form : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Molecular Mass : | 95.9 kDa |
Protein length : | 1 a.a. - 622 a.a. |
AA Sequence : | MKENVASATVFTLLLFLNTCLLNGQ LPPGKPEIFKCRSPNKETFTCWWRP GTDGGLPTNYSLTYHREGETLMHEC PDYITGGPNSCHFGKQYTSMWRTYI MMVNATNQMGSSFSDELYVDVTYIV QPDPPLELAVEVKQPEDRKPYLWIK WSPPTLIDLKTGWFTLLYEIRLKPE KAAEWEIHFAGQQTEFKILSLHPGQ KYLVQVRCKPDHGYWSAWSPATFIQ IPSDFTMNDTTVWISVAVLSAVICL IIVWAVALKGYSMVTCIFPPVPGPK IKGFDAHLLEKGKSEELLSALGCQD FPPTSDYEDLLVEYLEVDDSEDQHL MSVHSKEHPSQGMKPTYLDPDTDSG RGSCDSPSLLSEKCEEPQANPSTFY DPEVIEKPENPETTHTWDPQCISME GKIPYFHAGGSKCSTWPLPQPSQHN PRSSYHNITDVCELAVGPAGAPATL LNEAGKDALKSSQTIKSREEGKATQ QREVESFHSETDQDTPWLLPQEKTP FGSAKPLDYVEIHKVNKDGALSLLP KQRENSGKPKKPGTPENNKEYAKVS GVMDNNILVLVPDPHAKNVACFEES AKEAPPSLEQNQAEKALANFTATSS KCRLQLGGLDYLDPACFTHSFH |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Gene Name : | PRLR prolactin receptor [ Homo sapiens ] |
Official Symbol : | PRLR |
Synonyms : | PRLR; prolactin receptor; PRL-R; hPRL receptor; secreted prolactin binding protein; hPRLrI; |
Gene ID : | 5618 |
mRNA Refseq : | NM_000949 |
Protein Refseq : | NP_000940 |
MIM : | 176761 |
UniProt ID : | P16471 |
Chromosome Location : | 5p14-p13 |
Pathway : | Adipogenesis, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; ErbB4 signaling events, organism-specific biosystem; Growth hormone receptor signaling, organism-specific biosystem; Immune System, organism-specific biosystem; |
Function : | cytokine receptor activity; metal ion binding; ornithine decarboxylase activator activity; peptide hormone binding; prolactin receptor activity; protein homodimerization activity; receptor activity; |
Products Types
◆ Recombinant Protein | ||
PRLR-4360R | Recombinant Rat PRLR Protein, His (Fc)-Avi-tagged | +Inquiry |
PRLR-1247M | Recombinant Mouse PRLR protein(Met1-Asp229), His-tagged | +Inquiry |
Prlr-6389R | Recombinant Rat Prlr Protein, His (Fc)-Avi-tagged | +Inquiry |
PRLR-135H | Recombinant Human PRLR Protein, His (Fc)-Avi-tagged | +Inquiry |
PRLR-720H | Recombinant Human PRLR Protein, His-tagged | +Inquiry |
◆ Lysates | ||
PRLR-1740RCL | Recombinant Rat PRLR cell lysate | +Inquiry |
PRLR-1451MCL | Recombinant Mouse PRLR cell lysate | +Inquiry |
PRLR-2722HCL | Recombinant Human PRLR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionPRLR overexpression or dysregulation has been associated with breast cancer. It can promote cell proliferation and survival through aberrant signaling pathways.
Tissue-specific factors and the presence of co-receptors contribute to the diversity of PRLR signaling outcomes in different tissues and cell types.
The JAK-STAT signaling pathway is a primary pathway activated by PRLR. It involves the activation of Janus kinases (JAKs) and signal transducers and activators of transcription (STATs).
PRLR undergoes endocytosis upon ligand binding, and the internalized receptor-ligand complex is trafficked through intracellular compartments, influencing downstream signaling and receptor recycling.
Phosphorylation is a crucial post-translational modification of PRLR, affecting its activation and downstream signaling. Other modifications, such as glycosylation, also play roles.
Customer Reviews (3)
Write a reviewConsistent quality shines through—this protein has become indispensable.
This protein streamlines our experiments.
Fast shipping made this purchase convenient for our lab operations.
Ask a Question for All PRLR Products
Required fields are marked with *
My Review for All PRLR Products
Required fields are marked with *
Inquiry Basket