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Recombinant Human PRLR protein, GST-tagged

Cat.No. : PRLR-59H
Product Overview : Recombinant Human PRLR(1 a.a. - 622 a.a.) fused with GST tag at N-terminal was expressed in NS0.
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Description : This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer.
Source : Wheat Germ
Species : Human
Tag : GST
Form : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Molecular Mass : 95.9 kDa
Protein length : 1 a.a. - 622 a.a.
AA Sequence : MKENVASATVFTLLLFLNTCLLNGQ LPPGKPEIFKCRSPNKETFTCWWRP GTDGGLPTNYSLTYHREGETLMHEC PDYITGGPNSCHFGKQYTSMWRTYI MMVNATNQMGSSFSDELYVDVTYIV QPDPPLELAVEVKQPEDRKPYLWIK WSPPTLIDLKTGWFTLLYEIRLKPE KAAEWEIHFAGQQTEFKILSLHPGQ KYLVQVRCKPDHGYWSAWSPATFIQ IPSDFTMNDTTVWISVAVLSAVICL IIVWAVALKGYSMVTCIFPPVPGPK IKGFDAHLLEKGKSEELLSALGCQD FPPTSDYEDLLVEYLEVDDSEDQHL MSVHSKEHPSQGMKPTYLDPDTDSG RGSCDSPSLLSEKCEEPQANPSTFY DPEVIEKPENPETTHTWDPQCISME GKIPYFHAGGSKCSTWPLPQPSQHN PRSSYHNITDVCELAVGPAGAPATL LNEAGKDALKSSQTIKSREEGKATQ QREVESFHSETDQDTPWLLPQEKTP FGSAKPLDYVEIHKVNKDGALSLLP KQRENSGKPKKPGTPENNKEYAKVS GVMDNNILVLVPDPHAKNVACFEES AKEAPPSLEQNQAEKALANFTATSS KCRLQLGGLDYLDPACFTHSFH
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Gene Name : PRLR prolactin receptor [ Homo sapiens ]
Official Symbol : PRLR
Synonyms : PRLR; prolactin receptor; PRL-R; hPRL receptor; secreted prolactin binding protein; hPRLrI;
Gene ID : 5618
mRNA Refseq : NM_000949
Protein Refseq : NP_000940
MIM : 176761
UniProt ID : P16471
Chromosome Location : 5p14-p13
Pathway : Adipogenesis, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; ErbB4 signaling events, organism-specific biosystem; Growth hormone receptor signaling, organism-specific biosystem; Immune System, organism-specific biosystem;
Function : cytokine receptor activity; metal ion binding; ornithine decarboxylase activator activity; peptide hormone binding; prolactin receptor activity; protein homodimerization activity; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does PRLR contribute to the development of breast cancer at the molecular level? 04/17/2022

PRLR overexpression or dysregulation has been associated with breast cancer. It can promote cell proliferation and survival through aberrant signaling pathways.

How does PRLR signaling vary in different tissues? 05/09/2021

Tissue-specific factors and the presence of co-receptors contribute to the diversity of PRLR signaling outcomes in different tissues and cell types.

What are the key signaling pathways activated by the PRLR protein? 02/22/2020

The JAK-STAT signaling pathway is a primary pathway activated by PRLR. It involves the activation of Janus kinases (JAKs) and signal transducers and activators of transcription (STATs).

Explain the process of endocytosis and intracellular trafficking of PRLR. 01/01/2020

PRLR undergoes endocytosis upon ligand binding, and the internalized receptor-ligand complex is trafficked through intracellular compartments, influencing downstream signaling and receptor recycling.

Discuss the post-translational modifications involved in regulating PRLR activity. 11/28/2018

Phosphorylation is a crucial post-translational modification of PRLR, affecting its activation and downstream signaling. Other modifications, such as glycosylation, also play roles.

Customer Reviews (3)

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Reviews
04/03/2022

    Consistent quality shines through—this protein has become indispensable.

    02/24/2021

      This protein streamlines our experiments.

      12/22/2018

        Fast shipping made this purchase convenient for our lab operations.

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