Recombinant Human PRSS1 protein, Fc/His-tagged
Cat.No. : | PRSS1-5894H |
Product Overview : | Recombinant Human PRSS1(Ala16-Ser247) fused with Fc/His tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
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Description : | Trypsin-1, also known as Beta-trypsin, Cationic trypsinogen, Serine protease 1, Trypsin I, TRP1, TRY1, TRY4, TRYP1 and PRSS1, is a member of the trypsin family of serine proteases. PRSS1 contains one peptidase S1 domain and binds one calcium ion per subunit. PRSS1 is secreted by the pancreas and cleaved to its active form in the small intestine. Trypsin-1 is active on peptide linkages involving the carboxyl group of lysine or arginine. Defects in PRSS1 are a cause of pancreatitis (PCTT), which characterized by the presence of calculi in pancreatic ducts. |
Source : | HEK293 |
Species : | Human |
Tag : | Fc/His |
Form : | Supplied as a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
Molecular Mass : | 52.9 kDa |
Protein length : | Ala16-Ser247 |
AA Sequence : | APFDDDDKIVGGYNCEENSVPYQVS LNSGYHFCGGSLINEQWVVSAGHCY KSRIQVRLGEHNIEVLEGNEQFINA AKIIRHPQYDRKTLNNDIMLIKLSS RAVINARVSTISLPTAPPATGTKCL ISGWGNTASSGADYPDELQCLDAP VLSQAKCEASYPGKITSNMFCVGFL EGGKDSCQGDSGGPVVCNGQLQGVV SWGDGCAQKNKPGVYTKVYNYVKWI KNTIAANSVDDIEGRMDEPKSCDKT HTCPPCPAPELLGGPSVFLFPPKPK DTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPREEQYN STYRVVSVLTVLHQDWLNGKEYKCK VSNKALPAPIEKTISKAKGQPREP QVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPP VLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPG KHHHHHH |
Endotoxin : | Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test. |
Purity : | Greater than 95% as determined by reducing SDS-PAGE. |
Storage : | Please minimize freeze-thaw cycles. |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Gene Name : | PRSS1 protease, serine, 1 (trypsin 1) [ Homo sapiens ] |
Official Symbol : | PRSS1 |
Synonyms : | PRSS1; protease, serine, 1 (trypsin 1); TRY1; trypsin-1; beta-trypsin; trypsinogen 1; trypsinogen A; digestive zymogen; cationic trypsinogen; nonfunctional trypsin 1; TRP1; TRY4; TRYP1; FLJ57296; MGC120175; MGC149362; DKFZp779A0837; |
Gene ID : | 5644 |
mRNA Refseq : | NM_002769 |
Protein Refseq : | NP_002760 |
MIM : | 276000 |
UniProt ID : | P07477 |
Chromosome Location : | 7q34 |
Pathway : | Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem; |
Function : | metal ion binding; peptidase activity; serine-type endopeptidase activity; |
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◆ Native Protein | ||
PRSS1-30745TH | Active Native Human PRSS1 | +Inquiry |
◆ Lysates | ||
PRSS1-2806HCL | Recombinant Human PRSS1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe structure of PRSS1 determines its ability to bind specifically to the substrate and the efficiency of the catalytic reaction. The study of its structure can help us understand its function and mechanism of action.
PRSS1 can interact with other digestive enzymes, such as stomach acid and bile, to participate in the digestive process of food.
It is primarily involved in the digestion of proteins in the digestive system, breaking them down into small peptides and amino acids.
Therapeutic strategies for PRSS1 may include supplementing or inhibiting its expression and regulating its interaction with other digestive enzymes. These methods may have potential applications in treating diseases such as pancreatitis or pancreatic cancer.
The expression of PRSS1 in the pancreas is determined by factors such as its substrate specificity and synergies with other digestive enzymes. In other organs, its expression may vary by different regulatory mechanisms.
Lack of PRSS1 may lead to protein digestion disorders, while overexpression of PRSS1 may lead to diseases such as pancreatitis or pancreatic cancer.
Customer Reviews (3)
Write a reviewThe pharmacodynamic parameters of PRSS1 were good.
PRSS1 has very high sensitivity in Western blot and can detect low concentrations of the protein of interest.
PRSS1 has good compatibility and stability with various excipients.
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