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Recombinant Human PRSS1 protein, Fc/His-tagged

Cat.No. : PRSS1-5894H
Product Overview : Recombinant Human PRSS1(Ala16-Ser247) fused with Fc/His tag at C-terminal was expressed in HEK293.
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Description : Trypsin-1, also known as Beta-trypsin, Cationic trypsinogen, Serine protease 1, Trypsin I, TRP1, TRY1, TRY4, TRYP1 and PRSS1, is a member of the trypsin family of serine proteases. PRSS1 contains one peptidase S1 domain and binds one calcium ion per subunit. PRSS1 is secreted by the pancreas and cleaved to its active form in the small intestine. Trypsin-1 is active on peptide linkages involving the carboxyl group of lysine or arginine. Defects in PRSS1 are a cause of pancreatitis (PCTT), which characterized by the presence of calculi in pancreatic ducts.
Source : HEK293
Species : Human
Tag : Fc/His
Form : Supplied as a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.
Molecular Mass : 52.9 kDa
Protein length : Ala16-Ser247
AA Sequence : APFDDDDKIVGGYNCEENSVPYQVS LNSGYHFCGGSLINEQWVVSAGHCY KSRIQVRLGEHNIEVLEGNEQFINA AKIIRHPQYDRKTLNNDIMLIKLSS RAVINARVSTISLPTAPPATGTKCL ISGWGNTASSGADYPDELQCLDAP VLSQAKCEASYPGKITSNMFCVGFL EGGKDSCQGDSGGPVVCNGQLQGVV SWGDGCAQKNKPGVYTKVYNYVKWI KNTIAANSVDDIEGRMDEPKSCDKT HTCPPCPAPELLGGPSVFLFPPKPK DTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPREEQYN STYRVVSVLTVLHQDWLNGKEYKCK VSNKALPAPIEKTISKAKGQPREP QVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPP VLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPG KHHHHHH
Endotoxin : Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Purity : Greater than 95% as determined by reducing SDS-PAGE.
Storage : Please minimize freeze-thaw cycles.
Reconstitution : Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Gene Name : PRSS1 protease, serine, 1 (trypsin 1) [ Homo sapiens ]
Official Symbol : PRSS1
Synonyms : PRSS1; protease, serine, 1 (trypsin 1); TRY1; trypsin-1; beta-trypsin; trypsinogen 1; trypsinogen A; digestive zymogen; cationic trypsinogen; nonfunctional trypsin 1; TRP1; TRY4; TRYP1; FLJ57296; MGC120175; MGC149362; DKFZp779A0837;
Gene ID : 5644
mRNA Refseq : NM_002769
Protein Refseq : NP_002760
MIM : 276000
UniProt ID : P07477
Chromosome Location : 7q34
Pathway : Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function : metal ion binding; peptidase activity; serine-type endopeptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the relationship between PRSS1's structure and function? 08/16/2023

The structure of PRSS1 determines its ability to bind specifically to the substrate and the efficiency of the catalytic reaction. The study of its structure can help us understand its function and mechanism of action.

What are the interactions between PRSS1 and other digestive enzymes? 06/03/2023

PRSS1 can interact with other digestive enzymes, such as stomach acid and bile, to participate in the digestive process of food.

Which is the main function of PRSS1 in the digestive system? 01/06/2023

It is primarily involved in the digestion of proteins in the digestive system, breaking them down into small peptides and amino acids.

What are the therapeutic strategies for PRSS1? 05/03/2021

Therapeutic strategies for PRSS1 may include supplementing or inhibiting its expression and regulating its interaction with other digestive enzymes. These methods may have potential applications in treating diseases such as pancreatitis or pancreatic cancer.

Why is PRSS1 expressed in the pancreas but not in other organs? 08/23/2020

The expression of PRSS1 in the pancreas is determined by factors such as its substrate specificity and synergies with other digestive enzymes. In other organs, its expression may vary by different regulatory mechanisms.

How about the effects of lack or overexpression of PRSS1? 07/18/2020

Lack of PRSS1 may lead to protein digestion disorders, while overexpression of PRSS1 may lead to diseases such as pancreatitis or pancreatic cancer.

Customer Reviews (3)

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Reviews
06/02/2023

    The pharmacodynamic parameters of PRSS1 were good.

    12/20/2022

      PRSS1 has very high sensitivity in Western blot and can detect low concentrations of the protein of interest.

      05/19/2021

        PRSS1 has good compatibility and stability with various excipients.

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